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Adipogen/anti-LRP5/6, mAb (rec.) (Heldy-1-4)/AG-27B-0019-C100/100 µg
Adipogen/anti-LRP5/6, mAb (rec.) (Heldy-1-4)/AG-27B-0019-C100/100 µg
商品编号：
AG-27B-0019-C100
品牌：
Adipogen Inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Low-densityLipoproteinReceptor-relatedProtein5;LRP-5;Low-densityLipoproteinReceptor-relatedProtein6;LRP-6 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | Heldy-1-4 |
| Isotype | HumanIgG2&lamBDa;. |
| Source/Host | HEK293cells |
| Immunogen/Antigen | RecombinantmouseLRP6. |
| Application | FlowCytometry:1/100dilution |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseLRP5&LRP6. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glycerol. |
| OtherProductData | anti-LRP5/6(human),mAb(rec.)(Heldy-1-4)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothehumanlgG2Fcdomain. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Wnt/β-cateninsignalingactsasaregulatoroftissuedevelopmentandhomeostasis.WntligandsbindtoamemberoftheFrizzledfamilyofseven-transmembraneproteinsandtoeitherhighlyhomologouslow-densitylipoproteinrelatedreceptors5(LRP5)orLRP6.Low-densitylipoproteinreceptor-relatedprotein6(LRP6)isamemberofthelow-densitylipoproteinreceptor(LDLR)family.LRP5andLRP6areexpressedinmosthumantissuesandiscomposedofthreedistinctivecell-surfaceproteindomains,including(1)LDLreceptor(LDLR)typeArepeats;(2)anepidermalgrowthfactor(EGF)-likedomain;and(3)aYWTD(Tyr-Trp-Thr-Asp)-typeβpropellerdomain.LRP6isinhibitedbytheDickkopfproteinDkk1boundtotheirpartnersKremen.SclerotinalsoactsasaninhibitorofLRP5/6throughLRP4.LRP6isinvolvedincelldifferentiation,proliferationandmigrationduringembryonicdevelopmentandinthepathogenesisofdifferentcancertypes.LRP6playsamajorroleinmetabolicregulation,specificallyinthenutrient-sensingpathway.PatientscarryinganLRP6mutationexhibithighserumLDLcholesterolandtriglycerides,hypertension,highfastingbloodglucoselevels,aprevalenceofdiabetesandlowbonedensity.LRP6mutationshavealsobeenassociatedwithdiseasessuchasAlzheimer"sanddegenerativejointdiseases.LRP5,low-density-lipoprotein-receptor-relatedprotein5,isadeterminantforbonemineraldensityandplaysaroleinosteoporosis.LRP5isasoinvolvedinvitreoretinopathy.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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