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Adipogen/anti-Lewis<sup>y/b</sup> hapten (human), mAb (SC104) (preservative free)/AG-20B-6002PF-C100/100 µg
Adipogen/anti-Lewis<sup>y/b</sup> hapten (human), mAb (SC104) (preservative free)/AG-20B-6002PF-C100/100 µg
商品编号：
AG-20B-6002PF-C100
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Sialyltetraosylceramide;NCRC37 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | SC104 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | Tissueculturedcolorectaltumorcelllines(C170,C146,Colo205andJW). |
| Application | ELISA: FlowCytometry:(directandindirect) FunctionalApplication:Directlyinducestumor-specificcelldeathwithouttheneedforimmuneeffectorcellsbyinductionofcaspase-mediatedapoptosis.Optimalconcentrationsusedtoinducetumourcelldeathinvitroandinvivoarebetween10-30μg/ml. Immunocytochemistry:(1-5μg/ml) Immunohistochemistry:(paraffinsections;1μg/ml) |
| Crossreactivity | Human |
| Specificity | Recognizeshumansialyltetraosylceramide.Doesnotbindtobloodlympocytes,granulocytes,bonemarrowProgenitorcells,GM1,GD1a,GT1borsialylLewisXantigens. |
| Purity | ≥95%(SDS-PAGE) |
| EndotoxinContent | <0.001eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | Lotdependent |
| Formulation | Liquid.InPBS. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Membraneglycolipidsrepresentanunexploredsourceoftumor-associatedantigens.Manyoftheseareoverexpressedandalteredintumorscomparedtonormaltissue.Researchintoaberrantglycosylationandover-expressionofglycolipidsonthesurfaceofthemajorityofcancers,coupledwithaknowledgeofglycolipidsasfunctionalmoleculesinvolvedinanumberofcellularphysiologicalpathways,hasprovidedanovelareaoftargetsforcancerimmunotherapy.Lewis-y/bisacellsurfacecarbohydratebloodgroupantigenexpressedatverylowlevelsinnormaltissue,butoftenfoundtobeoverexpressedonbreast,lung,colonandovariancancercells.CloneSC104recognizesauniquecellsurfaceantigensialyltetraosylceramide,expressedby90%ofcolorectaltumorsatallclinicalstages.SC104targetscolorectalcancer-associatedglycolipidsandinducestumorcelldeathinvitroindependentlyofCDCorADCCorblockadeofknownsurvivalsignalingpathways.Itinducesapoptoticcelldeathandsynergizeswithchemotherapyinvivoinmice.
ProductReferences
- DevelopmentofsecondgenerationmonoclonalantibodiesrecognisingLewisy/bantigenbyanti-idiotypicimmunisation:L.G.Durrant,etal.;Hybridoma12,647(1993)
- Anewanticancerglycolipidmonoclonalantibody,SC104,whichdirectlyinducestumorcellapoptosis:L.G.Durrant,etal.;CancerRes.66,5901(2006)
- Immunologyintheclinicreviewseries;focusoncancer:glycolipidsastargetsfortumourimmunotherapy:L.G.Durrant,etal.;Clin.Exp.Immunol.167,206(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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