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Adipogen/anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)/AG-20B-0012PF-C100/100 µg
Adipogen/anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)/AG-20B-0012PF-C100/100 µg
商品编号：
AG-20B-0012PF-C100
品牌：
Adipogen Inc
市场价：
¥6300.00
美元价：
3780.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | LymphocyteActivationGene-3;FDCProtein;CD223 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 17B4 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | Syntheticpeptidecorrespondingto30aaintheN-terminusofhumanLAG-3. |
| Application | FlowCytometry FunctionalApplication:Inhibition Immunocytochemistry Immunohistochemistry:(frozensections(1:150)) Immunoprecipitation:(10μg/ml) WesternBlot:(5μg/ml) |
| Crossreactivity | Human |
| Specificity | RecognizeshumanLAG-3. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| EndotoxinContent | <0.001EU/μgpurifiedproteinor<1EU/mgpurifiedprotein(LALtest;Lonza). |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBS. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Lymphocyteactivationgene3(LAG-3;CD223)playsanimportantroleinnegativelyregulatingTcellproliferation,functionandhomeostasis.ItisrequiredformaximalnaturalandinducedregulatoryTcell(Treg)function.LAG-3iscloselyrelatedtotheTcellco-receptorCD4andbindstoMHCclassIImoleculesbutwithasignificantlyhigheraffinitythanCD4.
ProductReferences
- Characterizationofthelymphocyteactivationgene3-encodedprotein.AnewligandforhumanleukocyteantigenclassIIantigens:E.Baixeras,etal.;J.Exp.Med.176,327(1992)
- CellularexpressionandtissuedistributionofthehumanLAG-3-encodedprotein,anMHCclassIIligand:B.Huard,etal.;Immunogenetics39,213(1994)
- CharacterizationofthemajorhistocompatibilitycomplexclassIIbindingsiteonLAG-3protein:B.Huard,etal.;PNAS94,5744(1997)
- CD3/TCRcomplex-associatedlymphocyteactivationgene-3moleculesinhibitCD3/TCRsignaling:S.Hannier,etal.;J.Immunol.161,4058(1998)
- TLymphocytesinfiltratingvarioustumourtypesexpresstheMHCclassIIligandlymphocyteactivationgene-3(LAG-3):roleofLAG-3/MHCclassIIinteractionsincell-cellcontacts:C.E.Demeure,etal.;Eur.J.Cancer37,1709(2001)
- Immunologicalmechanismselicitedatthetumoursitebylymphocyteactivationgene-3(LAG-3)versusIL-12:sharingacommonTh1anti-tumourimmunepathway:E.D.Carlo,etal.;J.Pathol.205,82(2005)
- Thenegativeregulatoryfunctionofthelymphocyte-activationgene-3co-receptor(CD223)onhumanTcells:L.Macon-Lemaitre&F.Triebel;Immunology115,170(2005)
- Asolublelymphocyteactivationgene-3(sLAG-3)proteinasaprognosticfactorinhumanbreastcancerexpressingestrogenorprogesteronereceptors:F.Triebel,etal.;CancerLett.235,147(2006)
- HumandendriticcellsacquireasemimaturephenotypeandlymphnodehomingpotentialthroughinteractionwithCD4+CD25+regulatoryTcells:J.Bayry,etal.;J.Immunol.178,4184(2007)
- Humanlymphocyteactivationgene-3moleculesexpressedbyactivatedTcellsdelivercostimulationsignalfordendriticcellactivation:C.Casati,etal.;J.Immunol.180,3782(2008)
- Lymphocyteactivationgene3:anoveltherapeutictargetinchroniclymphocyticleukemia:M.Shapiro,etal.;Haematologica102,874(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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