Adipogen/anti-ILK, mAb (AF22F1)/YIF-LF-MA0309/100 µl
商品编号：
YIF-LF-MA0309
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ILK;ILK1;ILK-2;ILK-1;p59ILK;EC=2.7.11.1;Integrin-linkedProteinKinase;59kDaSerine/Threonine-ProteinKinase |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | AF22F1 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-ILKproteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Integrin-linkedkinase(ILK)isanadaptorandsignalingproteinthatcouplesintegrinstotheactinCytoskeletonandcoordinatessignaltransductionfromextracellularmatrixandgrowthfactors.ByinteractingwiththefocaladhesionproteinsPINCH,paxillin,andparvin,ILKregulatesintegrin-mediatedcelladhesionandcytoskeletaldynamicswithinfocaladhesionstoregulatecelladhesion,spreADIng,andmigration.ILKisinvolvedinthesuppressionofapoptosisandpromotionofcellsurvivalthroughthephosphorylationofAKT(Ser473),GSK-3(Ser9),myosinlightchain(Ser18/19),andaffixin.ILKactivityisstimulatedbyPI3kinaseandnegativelyregulatedbythetumorsuppressorPTEN.Receptor-proximalproteinkinaseregulatingintegrin-mediatedsignaltransduction.Mayactasamediatorofinside-outintegrinsignaling.FocaladhesionproteinpartofthecomplexILK-PINCH.Thiscomplexisconsideredtobeoneoftheconvergencepointsofintegrin-andgrowthfactor-signalingpathway.Couldbeimplicatedinmediatingcellarchitecture,adhesiontointegrinsubstratesandanchorage-dependentgrowthinepithelialcells.Phosphorylatesβ-1andβ-3integrinsubunitonserineandthreonineresidues,butalsoAKT1andGSK3B.
ProductReferences
1)Fieldingetal.,(2008)JCellBiol180(4):681-9.(General)
2)PersadSandDedharS,(2004)CancerMetastasisRev22(4):375–84.(General)
3)DedharS,(2000)CurrOpinCellBiol12(2):250-6.(General)
2)PersadSandDedharS,(2004)CancerMetastasisRev22(4):375–84.(General)
3)DedharS,(2000)CurrOpinCellBiol12(2):250-6.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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