Adipogen/anti-IDO (mouse), pAb/AG-25A-0032-C100/100 µg
商品编号：
AG-25A-0032-C100
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Indoleamine2,3-dioxygenase;INDO |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinantmouseIDO. |
| Application | ELISA:(directandindirect:1:2’000-1:10’000) Immunocytochemistry:(1:500-1:2’000) Immunohistochemistry:(paraffinsections(1:200-1:500)) WesternBlot:(1:2’000-1:5’000usingECL;suggestedblockinganddilutionbufferisPBSTcontaining0.05%Tween20and5%skimmilk;suggestedincubationtimeis1houratroomtemperature). Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseIDO.Detectsabandof~45kDabyWesternblot. |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.0.2μm-filteredsolutioninPBS,pH7.4.Containsnopreservatives. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IDOcatalyzesthefirstandrate-limitingstepinthemainpathwayofhumantryptophancatabolism,thekynureninepathway.Proinflammatorymediators,suchasendotoxinandIFN-γinducetheexpressionofIDOinseveraltissues.IDO-dependentsuppressionofT-cellresponsesmightfunctionasnaturalimmunoregulatorymechanism.PhysiologicalIDOactivityhasbeenimplicatedinT-celltolerancetotumors,dysfunctionalselftoleranceinnon-obesediabetic(NOD)mice,andasaprotectivenegativeregulatorinautoimmunedisorders.
ProductReferences
- IFN-gamma-inducedIDOandWRSexpressioninmicrogliaisdifferentiallyregulatedbyIL-4:M.C.Yadav,etal.;Glia55,1385(2007)
- Spontaneousrenalallograftacceptanceassociatedwith"regulatory"dendriticcellsandIDO:C.H.Cook,etal.;J.Immunol.180,3103(2008)
- BlockadeofIndoleamine2,3-DioxygenaseProtectsMiceagainstLipopolysaccharide-InducedEndotoxinShock:I.D.Jung,etal.;J.Immunol.182,3146(2009)
- Anovelcancertherapybyskindeliveryofindoleamine2,3-dioxygenasesiRNA:M.C.Yen,etal.;Clin.CancerRes.15,641(2009)
- Curcuminsuppressestheinductionofindoleamine2,3-dioxygenasebyblockingtheJanus-activatedkinase-proteinkinaseCdelta-STAT1signalingpathwayininterferon-gamma-stimulatedmurinedendriticcells:Y.I.Jeong,etal.;J.Biol.Chem.284,3700(2009)
- AcombinationofthemetabolicenzymeinhibitorAPO866andtheimmuneadjuvantL-1-methyltryptophaninducesadditiveantitumoractivity:H.J.Yang,etal.;Exp.Biol.Med.(Maywood)235,869(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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