Adipogen/anti-IDO (human), pAb/AG-25A-0029-C100/100 µg
商品编号：
AG-25A-0029-C100
品牌：
Adipogen Inc
市场价：
¥5900.00
美元价：
3540.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Indoleamine2,3-dioxygenase;INDO |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinanthumanIDO. |
| Application | ELISA:(directandindirect:1:2’000-1:10’000) FlowCytometry:(1:200-1:500) Immunocytochemistry:(1:500) WesternBlot:(1:2’000-1:5’000usingECL;suggestedblockinganddilutionbufferisPBSTcontaining0.05%Tween20and5%skimmilk;suggestedincubationtimeis1houratroomtemperature). Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | RecognizeshumanIDO.Detectsabandof~45kDabyWesternblot. |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.0.2μm-filteredsolutioninPBS,pH7.4.Containsnopreservatives. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast6monthsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
IDOcatalyzesthefirstandrate-limitingstepinthemainpathwayofhumantryptophancatabolism,thekynureninepathway.Proinflammatorymediators,suchasendotoxinandIFN-γinducetheexpressionofIDOinseveraltissues.IDO-dependentsuppressionofT-cellresponsesmightfunctionasnaturalimmunoregulatorymechanism.PhysiologicalIDOactivityhasbeenimplicatedinT-celltolerancetotumors,dysfunctionalselftoleranceinnon-obesediabetic(NOD)mice,andasaprotectivenegativeregulatorinautoimmunedisorders.
ProductReferences
- HIVinhibitsCD4+T-cellproliferationbyinducingindoleamine2,3-dioxygenaseinplasmacytoiddendriticcells:A.Boasso,etal.;Blood109,3351(2007)
- FunctionalAlterationoftheLymphomaStromalCellNichebytheCytokineContext:RoleofIndoleamine-2,3Dioxygenase:H.Maby-ElHajjami,etal.;CancerRes.69,3228(2009)
- Anovelcancertherapybyskindeliveryofindoleamine2,3-dioxygenasesiRNA:M.C.Yen,etal.;Clin.CancerRes.15,641(2009)
- Indoleamine2,3-dioxygenase-expressingleukemicdendriticcellsimpairaleukemia-specificimmuneresponsebyinducingpotentTregulatorycells:A.Curti,etal.;Haematologica95,2022(2010)
- Theindoleamine-2,3-dioxygenase(IDO)inhibitor1-methyl-D-tryptophanupregulatesIDO1inhumancancercells:C.A.Opitz,etal.;PLoSOne6,e19823(2011)
- Melanomacellsinhibitnaturalkillercellfunctionbymodulatingtheexpressionofactivatingreceptorsandcytolyticactivity:G.Pietra,etal.;CancerRes.72,1407(2012)
- InhibitionofIndoleamine-2,3-dioxygenase(IDO)inGlioblastomaCellsbyOncolyticHerpesSimplexVirus:B.Reinhart,etal.;Adv.Virol.2012,815465(2012)
- AnAutocrineCytokine/JAK/STAT-SignalingInducesKynurenineSynthesisinMultidrugResistantHumanCancerCells:I.Campia,etal.;PLoSOne10,e0126159(2015)
- Tumorindoleamine2,3-dioxygenase(IDO)inhibitsCD19-CARTcellsandisdownregulatedbylymphodepletingdrugs:S.Ninomiya,etal.;Blood125,3905(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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