Adipogen/anti-ICAD, mAb (AF24G5)/YIF-LF-MA0300/100 µl
商品编号：
YIF-LF-MA0300
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | H13; DFF1; ICAD; DFFA; DFF-45; Inhibitor of CAD; DNA Fragmentation Factor Subunit α; DNA Fragmentation Factor 45 kDa Subunit |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | AF24G5 |
| Isotype | Mouse IgG2a κ |
| Immunogen/Antigen | Recombinant human His-ICAD protein purified from E. coli. |
| Application |
ELISA Western Blot (1:2,000) Immunoprecipitation (3 μl) |
| Crossreactivity |
Human Mouse Rat |
| Purity Detail | Ammonium sulfate precipitation. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
The inhibitor of caspase-3-activated DNase (ICAD) is a caspase 3 substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone. There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells. Inhibitor of the caspase-activated DNase (DFF40).
Product References
1) Enari M et al, Nature. (1998) vol.391(6662): pp.43-50. (General)
2) Sakahira H et al, J Biol Chem. (1999) vol.274(22): p.15740-4. (General)
3) Charrier L et al, Cancer Res. (2002) vol.62(7): p.2169-74. (General)
4) Fukushima K et al, J Mol Biol. (2002) vol.321(2): p.317-27. (General)
2) Sakahira H et al, J Biol Chem. (1999) vol.274(22): p.15740-4. (General)
3) Charrier L et al, Cancer Res. (2002) vol.62(7): p.2169-74. (General)
4) Fukushima K et al, J Mol Biol. (2002) vol.321(2): p.317-27. (General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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