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Adipogen/anti-ICAD (Inhibitor of CAD DFF45), pAb/YIF-LF-PA0058/100 µl
Adipogen/anti-ICAD (Inhibitor of CAD DFF45), pAb/YIF-LF-PA0058/100 µl
商品编号：
YIF-LF-PA0058
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | H13;DFFA;ICAD;DFF1;DFF-45;InhibitorofCAD;DNAFragmentationFactorSubunitα;DNAFragmentationFactor45kDaSubunit |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:2,000) Immunoprecipitationnottested. |
| Crossreactivity | Human |
| PurityDetail | ProteinApurified. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Theinhibitorofcaspase-3-activatedDNase(ICAD)isacaspase-3substratethatcontrolsnuclearapoptosis.ICADhastwoisoforms:afunctionalisoformofM.W.45kDa,ICAD-L/DNAfragmentationfactor(DFF)45;andaM.W.35kDaisoform,ICAD-S/DFF35.AlthoughbothICAD-LandICAD-ScanbindandinhibitCAD,onlyICAD-Lwasreportedtobefunctional.ICADiscleavedtobeinactivatedandallowcaspase-activatedDNase(CAD)toexecutenuclearinternucleosomalapoptoticDNAfragmentation.Innon-apoptoticcells,CADiscomplexedwithitsinhibitor,ICAD.TheactivationoftheCAD/ICADcomplexoccursthroughthecaspase3-mediatedcleavageofICADatresidues117and224,whichresultsinthreeICADfragmentsthatarethenreleasedfromCAD.InadditiontoitsDNaseinhibitoryactivity,ICADactsasaCAD-specificfoldingchaperone.TherearerecentreportsthatICADisapotentialtargetforrestoringanormalapoptoticsignaltransductionpathwayincolonandbraincancercells.Inhibitorofthecaspase-activatedDNase(DFF40).
ProductReferences
1)EnariMetal,Nature.1998;vol.391(6662):pp.43-50.(General)
2)SakahiraHetal,JBiolChem.1999;vol.274(22):p.15740-4.(General)
3)CharrierLetal,CancerRes.2002;vol.62(7):p.2169-74.(General)
4)FukushimaKetal,JMolBiol.2002;vol.321(2):p.317-27.(General)
2)SakahiraHetal,JBiolChem.1999;vol.274(22):p.15740-4.(General)
3)CharrierLetal,CancerRes.2002;vol.62(7):p.2169-74.(General)
4)FukushimaKetal,JMolBiol.2002;vol.321(2):p.317-27.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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