Adipogen/anti-HPK1, mAb (2A1)/YIF-LF-MA0211/100 µl
商品编号：
YIF-LF-MA0211
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HPK1;MAP4K1;MEKKK1;EC=2.7.11.1;MEKKinaseKinase1;MAPK/ERKKinaseKinaseKinase1;HematopoieticProgenitorKinase;Mitogen-activatedProteinKinaseKinaseKinaseKinase1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 2A1 |
| Isotype | MouseIgG1&lamBDa; |
| Immunogen/Antigen | RecombinanthumanHis/ABD-HPK1proteinpurifiedfromE.coli. |
| Application | WesternBlot(1:5,000) Immunoprecipitation(3μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Hematopoieticprogenitorkinase1(HPK1)isa97kDaserine/threonineproteinkinaseexpressedonlyinhematopoieticcellsandtissues.HPK1iscomprosedofaSTE20-likekinasedomaininitsN-terminus,fourproline-richmotifs(-P-x-x-P-),acaspasecleavagesite,andadistalC-terminalCitronhomologydomain.Theproline-richmotifsarecapableofbindingproteinsthatcontainSH3domains.HPK1isinvolvedinmanycellularsignalingcascadesthatincludeMAPKsignaling,antigenreceptorsignaling,apoptosis,growthfactorsignaling,andcytokinesignaling.HPK1bindsmanyadaptorproteinsincludingmembersoftheGrb2family,Nckfamily,Crkfamily,SLP-76family,andactin-bindingadaptors.HPK1contains13potentialtyrosinephosphorylationresidues,someofwhichmaybephosphorylatedbyZAP-70,whichprovidepotentialdockingsitesforSH2domainscontainingproteins.HPK1isactivatedbybothEGFandPDGFstimulationwhereadaptorproteinsareinvolvedinmediatingthelocalizationofeffectormoleculestocellsurfacereceptors.Activation-inducedcelldeath(AICD)-resistantTcellscontainfull-lengthHPK1,whileAICD-sensitiveTcellshaveHPK1-C(cleavedform).HPK1mightbeapossIBLemolecularswitchusedtodiscriminatebetweentheextrinsicpathwayinvolvingdeathreceptorsandtheintrinsicpathwaydeterminedbytheratiobetweenanti-andpro-apoptoticBcl-2familymembers.Mayplayaroleintheresponsetoenvironmentalstress.AppearstoactupstreamoftheJUNN-terminalpathway.Mayplayaroleinhematopoieticlineagedecisionsandgrowthregulation.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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