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Adipogen/anti-HMGB1, mAb (rec.) (Giby-1-4)/AG-27B-0002-C100/100 µg
Adipogen/anti-HMGB1, mAb (rec.) (Giby-1-4)/AG-27B-0002-C100/100 µg
商品编号：
AG-27B-0002-C100
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | HighMobilityGroupProteinB1 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | Giby-1-4 |
| Isotype | HumanIgG2&lamBDa; |
| Source/Host | Purifiedfrom HEK293cell culturesupernatant. |
| Immunogen/Antigen | HumanrecombinantHMGB1. |
| Application | ELISA Westernblot:(1:1000) |
| Crossreactivity | Human Mouse Rat |
| Specificity | Recognizeshuman,mouseandratHMGB1. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| OtherProductData | HMGB1,monoclonalantibody(recombinant)(Giby1-4)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothehumanlgG2Fcdomain. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1monthafterreceiptwhenstoredat+4°C. Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
HMGB1wasoriginallydiscoveredasanessentialDNA-bindingproteinforregulatingp53,NF-κBandotherimportantproteins.Itissecretedfromactivateddentriccells,macrophageandnectroticcells,andactsasaligandforRAGE,TLR-2andTLR-4expressedonsurroundingcells.Asaresult,HMGB1activatesRac,CDC42andNF-κBinducinglocalizedinnateimmunityofdamagedtissue,tissueregenerationbyrecruitmentofstemcellsandhemostasisbyinductionoftissuefactorexpression.HMGB1isalsoacausativeagentofvariousdiseasesasitcauseslocalizedinflammationsuchasarteriosclerosis,chronicrheumatoidarthritisandnephritis.
Anti-HMGB1,mAb(recombinant)(Giby-1-4)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
Anti-HMGB1,mAb(recombinant)(Giby-1-4)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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