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Adipogen/anti-Hairy and Enhancer of Split 1 (HES), mAb (7H11)/YIF-LF-MA0184/100 µl
Adipogen/anti-Hairy and Enhancer of Split 1 (HES), mAb (7H11)/YIF-LF-MA0184/100 µl
商品编号：
YIF-LF-MA0184
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | hHL;HES1;BHLHB39;bHLHb39;HairyHomolog;Hairy-likeProtein;TranscriptionFactorHES-1;HairyandEnhancerofSplit1;ClassBBasicHelix-Loop-HelixProtein39 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 7H11 |
| Isotype | MouseIgG2bκ |
| Immunogen/Antigen | RecombinanthumanHis-Hes1proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:500~1,000) Immunoprecipitation(1μl) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
TheNotchsignalingpathwayisimportantforcell-cellcommunication,whichinvolvegeneregulationmechanismsthatcontrolmultiplecelldifferentiationprocessesduringembryonicandadultlife.Itcriticallyinfluencescellproliferation,differentiation,andapoptosisinmetazoans.Thehairyandenhancerofsplit(HES)familyisabasichelix-loop-helix(bHLH)typetrancriptionalrepressorandactsasNotcheffectorsbynegativelyregulatingexpressionofdownstreamtargetgenessuchastissue-specifictranscriptionfactors.HES-1isanupstreamnegativeregulatorofRESTexpression.SilencingofthetranscriptionalrepressorRESTisrequiredforterminaldifferentiationofneuronalandβ-cells.RecentintegrativegenomicanalysesonHES/HEYfamilysuggestthatHES1andHES3aretargetgenesoftheembryonicstemcell-specificnetworkoftranscriptionfactors,andthatHES1,HES5,HEY1,HEY2andHEYLaretargetgenesofNotchsignalingpathway.
ProductReferences
1)Kato,M.andKato,M.,(2007)IntJOncol.31:461-466.(General)
2)ABDerrahmani,A.etal.,(2005)FEBSLett.579:6199-6204.(General)
3)Iso,T.etal.,(2003)JCellPhysiol.194:237-255.(General)
2)ABDerrahmani,A.etal.,(2005)FEBSLett.579:6199-6204.(General)
3)Iso,T.etal.,(2003)JCellPhysiol.194:237-255.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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