脂肪原/抗FOXP3（小鼠），单克隆抗体（MF333F）/AG-20A-0025-C100/100µg
商品编号：
AG-20A-0025-C100
品牌：
Adipogen Inc
市场价：
¥4800.00
美元价：
2880.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ForkheadBoxProteinP3;Scurfin |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | MF333F |
| Isotype | RatIgG2aκ |
| Immunogen/Antigen | RecombinantmouseFOXP3. |
| Application | ELISA:(directorindirect:1:2"000-1:10"000) Immunocytochemistry Immunohistochemistry(1:50-1:100,frozenorparaffinsections) Westernblot:(1:2"000-1:5"000usingECL.SuggestedblockinganddilutionbufferisTBSTwith0.05%Tween20and5%skimmilk.Suggestedincubationtimeis1houratrooomtemperature). Optimalconditionsshouldbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseFOXP3.Detectsabandof~46-49kDabyWesternblot. |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.0.2μm-filteredsolutioninPBS,pH7.4.Containsnopreservatives. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
FOXP3isinvolvedinimmunesystemresponses.ItfunctionsasthemasterregulatorinthedevelopmentandfunctionofregulatoryTcells.FOXproteinsbelongtotheforkhead/winged-helixfamilyoftranscriptionalregulatorsandarepresumedtoexertcontrolviasimilarDNAbindinginteractionsduringtranscription.DefectsinFOXP3arethecauseofimmunodeficiencypolyendocrinopathy,enteropathy,X-linkedsyndrome(IPEX);alsoknownasX-linkedautoimmunity-immunodeficiencysyndrome.IPEXischaracterizedbyneonatalonsetinsulin-dependentdiabetesmellitus,infections,secretorydiarrhea,trombocytopenia,anemiaandeczema.
ProductReferences
- AlternativelyactivateddendriticcellspreferentiallysecreteIL-10,expandFoxp3+CD4+Tcells,andinducelong-termorganallograftsurvivalincombinationwithCTLA4-Ig:Y.Y.Lan,etal.;J.Immunol.177,5868(2006)
- Dendriticcellsexpressingtransgenicgalectin-1delayonsetofautoimmunediabetesinmice:M.J.Perone,etal.;J.Immunol.177,5278(2006)
- ImmunosurveillanceofErbb2carcinogenesisintransgenicmiceisconcealedbyadominantregulatoryT-cellself-tolerance:E.Ambrosino,etal.;CancerRes.66,7734(2006)
- Regulatedcompartmentalizationofprogrammedcelldeath-1discriminatesCD4+CD25+restingregulatoryTcellsfromactivatedTcells:G.Raimondi,etal.;J.Immunol.176,2808(2006)
- Antimetastaticactivityofapreventivecancervaccine:P.Nanni,etal.;CancerRes.67,11037(2007)
- Rapamycin-conditioneddendriticcellsarepoorstimulatorsofallogeneicCD4+Tcells,butenrichforantigen-specificFoxp3+Tregulatorycellsandpromoteorgantransplanttolerance:H.R.Turnquist,etal.;J.Immunol.178,7018(2007)
- PretransplantinfusionofmesenchymalstemcellsprolongsthesurvivalofasemiallogeneichearttransplantthroughthegenerationofregulatoryTcells:F.Casiraghi,etal.;J.Immunol.181,3933(2008)
- Suppressionofautoimmunediabetesbysolublegalectin-1:M.J.Perone,etal.;J.Immunol.182,2641(2009)
- ProtectiveroleforTLR4signalinginatherosclerosisprogressionasrevealedbyinfectionwithacommonoralpathogen:C.Hayashi,etal.;J.Immunol.189,3681(2012)
- AccelerationofdiabetesdevelopmentinCXCchemokinereceptor3(CXCR3)-deficientNODmice:Y.Yamada,etal.;Diabetologia55,2238(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
