Adipogen/anti-FLIP, mAb (Dave-2)/AG-20B-0005-C100/100 µg
商品编号：
AG-20B-0005-C100
品牌：
Adipogen Inc
市场价：
¥7900.00
美元价：
4740.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | I-FLICE;CLARP;CASPER;Usurpin,CASH;FLAME-1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Dave-2 |
| Isotype | RatIgG2a |
| Immunogen/Antigen | RecombinanthumanFLIP(aa1-480). |
| Application | Immunoprecipitation WesternBlot Note:Notrecommendedforimmunohistochemistry. |
| Crossreactivity | Human Mouse |
| Specificity | Recognizesanepitope(aa1-200)presentinbothshort(FLIPS)andlong(FLIPL)splicevariantsofhumanandmouseFLIP. |
| Concentration | 1mg/ml. |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
FLIPisanapoptosisregulatorproteinwhichfunctionsasacruciallinkbetweencellsurvivalandcelldeathpathwaysinmammaliancellsandactsasaninhibitorofTNFRSF6mediatedapoptosis.Aproteolyticfragment(p43)islikelyretainedinthedeath-inducingsignalingcomplex(DISC)therebyblockingfurtherrecruitmentandprocessingofcaspase-8atthecomplex.FulllengthandshorterisoformshavebeenshowneithertoinduceapoptosisortoreduceTNFRSF-triggeredapoptosis.FLIPlacksenzymatic(caspase)activity.FLIPishighly expressedinskeletalmuscle,pancreas,heart,kidney,placentaandperipheralbloodleukocytes.
ProductReferences
- Fasengagementinducesthematurationofdendriticcells(DCs),thereleaseofinterleukin(IL)-1beta,andtheproductionofinterferongammaintheabsenceofIL-12duringDC-Tcellcognateinteraction:anewroleforFasligandininf:M.Rescigno,etal.;J.Exp.Med.192,1661(2000)
- ProteinkinaseCregulatesFADDrecruitmentanddeath-inducingsignalingcomplexformationinFas/CD95-inducedapoptosis:M.Gomez-Angelats&J.A.Cidlowski;J.Biol.Chem.276,44944(2001)
- NF-kBsignalsinducetheexpressionofc-FLIP:O.Micheau,etal.;Mol.Cell.Biol.21,5299(2001)
- Fas-associateddeathdomainprotein(FADD)andcaspase-8mediateup-regulationofc-FosbyFasligandandtumornecrosisfactor-relatedapoptosis-inducingligand(TRAIL)viaaFLICEinhibitoryprotein(FLIP)-regulatedpathway:D.Siegmund,etal.;J.Biol.Chem.276,32585(2001)
- FasaggregationdoesnotcorrelatewithFas-mediatedapoptosis:Y.Lee&E.Shacter;J.Immunol.167,82(2001)
- Thecaspase8inhibitorc-FLIP(L)modulatesT-cellreceptor-inducedproliferationbutnotactivation-inducedcelldeathoflymphocytes:S.M.Lens,etal.;Mol.Cell.Biol.22,5419(2002)
- Mitogen-ActivatedProteinKinase/ExtracellularSignal-RegulatedKinaseSignalinginActivatedTCellsAbrogatesTRAIL-InducedApoptosisUpstreamoftheMitochondrialAmplificationLoopandCaspase-8:T.S.Soderstrom,etal.;J.Immunol.169,2851(2002)
- CharacterizationofthehumanFLICE-inhibitoryproteinlocusandcomparisonoftheanti-apoptoticactivityoffourdifferentflipisoforms:M.Djerbi,etal.;Scand.J.Immunol.54,180(2002)
- c-FLIPefficientlyrescuesTRAF-2-/-cellsfromTNF-inducedapoptosis:C.Guiet,etal.;CellDeathDiffer.9,138(2002)
- ExpressionofthelongformofhumanFLIPbyretroviralgenetransferofhemopoieticstemcellsexacerbatesexperimentalautoimmuneencephalomyelitis:M.Djerbi,etal.;J.Immunol.170,2064(2003)
- ChemotherapyenhancesTNF-relatedapoptosis-inducingligandDISCassemblyinHT29humancoloncancercells:S.Lacour,etal.;Oncogene22,1807(2003)
- BileacidsstimulatecFLIPphosphorylationenhancingTRAIL-mediatedapoptosis:H.Higuchi,etal.;J.Biol.Chem.278,454(2003)
- Theanti-apoptoticfactorBcl-2canfunctionallysubstitutefortheBcellsurvivalbutnotforthemarginalzoneBcelldifferentiationactivityofBAFF:A.Tardivel,etal.;Eur.J.Immunol.34,509(2004)
- TargetingBcl-x(L)inesophagealsquamouscancertosensitizetochemotherapyplusTRAIL-inducedapoptosiswhilenormalepithelialcellsareprotectedbyblockadeofcaspase9:K.Kim,etal.;CellDeathDiffer.11,583(2004)
- Fas-associatedproteinwithdeathdomain(FADD)-independentrecruitmentofc-FLIPLtodeathreceptor5:T.G.Jin,etal.;J.Biol.Chem.279,55594(2004)
- TheE3ubiquitinligaseitchcouplesJNKactivationtoTNFalpha-inducedcelldeathbyinducingc-FLIP(L)turnover:L.Chang,etal.;Cell124,601(2006)
- AProtectiveRolefortheHumanSMG-1KinaseagainstTumorNecrosisFactor-α-inducedApoptosis:V.Oliveira,etal.;J.Biol.Chem.283,13174(2008)
- CellularFLIPinhibitsmyeloidcellactivationbysuppressingselectiveinnatesignaling:YJ.Wu,etal.;Reproduction150,367(2015)
- KnockdownofRIPK1markedlyexacerbatesmurineimmune-mediatedliverinjurythroughmassiveapoptosisofhepatocytes,independentofnecroptosisandinhibitionofNF-κB:J.Suda,etal.,J.Immunol.aheadofprint(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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