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Adipogen/anti-FLIP (human), mAb (NF6) (Biotin)/AG-20B-0056B-C050/50 µg
Adipogen/anti-FLIP (human), mAb (NF6) (Biotin)/AG-20B-0056B-C050/50 µg
商品编号：
AG-20B-0056B-C050
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | I-FLICE;CLARP;CASPER;Usurpin,CASH;FLAME-1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | NF6 |
| Isotype | MouseIgG1 |
| Immunogen/Antigen | RecombinanthumanFLIP(aa1-480). |
| Label/Conjugates | Biotin |
| Application | Immunocytochemistry Immunohistochemistry(paraffinsections) WesternBlot(1:1000) |
| Crossreactivity | Human |
| Specificity | Recognizesshort(FLIPS)andlong(FLIPL)splicevariantsofhumanFLIP.ThisantibodyrecognizesanepitopeintheN-terminalDEDregion(aa1-194). |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
FLIPisanapoptosisregulatorproteinwhichfunctionsasacruciallinkbetweencellsurvivalandcelldeathpathwaysinmammaliancellsandactsasaninhibitorofTNFRSF6mediatedapoptosis.Aproteolyticfragment(p43)islikelyretainedinthedeath-inducingsignalingcomplex(DISC)therebyblockingfurtherrecruitmentandprocessingofcaspase-8atthecomplex.FulllengthandshorterisoformshavebeenshowneithertoinduceapoptosisortoreduceTNFRSF-triggeredapoptosis.FLIPlacksenzymatic(caspase)activity.FLIPishighlyexpressedinskeletalmuscle,pancreas,heart,kidney,placentaandperipheralbloodleukocytes.
ProductReferences
- Theroleofc-FLIPinmodulationofCD95-inducedapoptosis:S.Scaffidi,etal.;J.Biol.Chem.274,1541(1999)
- AninducIBLepathwayfordegradationofFLIPproteinsensitizestumorcellstoTRAIL-inducedapoptosis:Y.Kim,etal.;J.Biol.Chem.277,22320(2002)
- Caspase-10isrecruitedtoandactivatedatthenativeTRAILandCD95death-inducingsignallingcomplexesinaFADD-dependentmannerbutcannotfunctionallysubstitutecaspase-8:M.R.Sprick,etal.;EMBOJ.21,4520(2002)
- EnhancementofApo2L/TRAIL(tumornecrosisfactor-relatedapoptosis-inducingligand)-inducedapoptosisinnon-smallcelllungcancercelllinesbychemotherapeuticagentswithoutcorrelationtotheexpressionlevelofcellularprotease:S.Frese,etal.;J.Thorac.Cardiovasc.Surg.123,168(2002)
- LackofProapoptoticActivityofSolubleCD95LigandIsDuetoItsFailuretoInduceCD95Oligomers:S.Jang,etal.;J.Int.Cyt.Res.23,441(2003)
- ProteasomeinhibitionresultsinTRAILsensitizationofprimarykeratinocytesbyremovingtheresistance-mediatingblockofeffectorcaspasematuration:M.Leverkus,etal.;Mol.Cell.Biol.23,777(2003)
- Suramininhibitsdeathreceptor-inducedapoptosisinvitroandfulminantapoptoticliverdamageinmice:S.T.Eichhorst,etal.;NatureMed.10,602(2004)
- Thec-FLIP-NH2terminus(p22-FLIP)inducesNF-kappaBactivation:A.Golks,etal.;J.Exp.Med.203,1295(2006)
- Caspase-2isactivatedattheCD95death-inducingsignalingcomplexinthecourseofCD95-inducedapoptosis:I.N.Lavrik,etal.;Blood108,559(2006)
- TheroleofCAP3inCD95signaling:newinsightsintothemechanismofprocaspase-8activation:A.Golks,etal.;CellDeathDiff.13,489(2006)
- Expressionofc-FLIPisprimarilydetectedindiffuselargeB-celllymphomaandHodgkin"slymphomaandcorrelateswithlackofcaspase8activation:I.S.vanHoudt,etal.;Histopathology51,778(2007)
- CD95StimulationResultsintheFormationofaNovelDeathEffectorDomainProtein-containingComplex:I.N.Lavrik,etal.;J.Biol.Chem.283,26401(2008)
- ANewC-terminalCleavageProductofProcaspase-8,p30,DefinesanAlternativePathwayofProcaspase-8Activation:J.C.Hoffmann,etal.;Mol.CellBiol.29,4431(2009)
- StoichiometryoftheCD95Death-InducingSignalingComplex:ExperimentalandModelingEvidenceforaDeathEffectorDomainChainModel:K.Schleich,etal.;Mol.Cell47,1(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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