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Adipogen/anti-Fas (human), mAb (APO-1-3) (preservative free)/AG-20B-0062PF-C050/50 µg
Adipogen/anti-Fas (human), mAb (APO-1-3) (preservative free)/AG-20B-0062PF-C050/50 µg
商品编号：
AG-20B-0062PF-C050
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CD95;APO-1;TNFRSF6;TumorNecrosisFactorReceptorSuperfamilyMember6;Apoptosis-mediatingSurfaceAntigenFAS |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | APO-1-3 |
| Isotype | MouseIgG3 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinanthumanFas. |
| Label/Conjugates | PreservativeFree |
| Application | FlowCytometry Immunoprecipitation WesternBlot FunctionalApplication:Inducesapoptosiswithorwithoutcross-linking(ProteinA),dependingoncelltype. Note:Optimalconditionsmustbedetermined. |
| Crossreactivity | Human |
| Specificity | RecognizeshumanFas. |
| Purity | ≥95%(SDS-PAGE) |
| Concentration | 1mg/ml. |
| Formulation | Liquid.InPBS. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Fas(CD95)isamemberofthedeathreceptor(DR)family,asubfamilyofthetumornecrosisfactorreceptorsuperfamily.TheformationoftheFasdeath-inducingsignalingcomplex(DISC)istheinitialstepofFassignaling.Activationofprocaspase-8attheDISCleadstotheinductionofDR-mediatedapoptosis.StimulationofFashasbeenalsoreportedtotriggernon-apoptoticpathways.Ithasbeenshownthatmembrane-boundFasLisessentialforthecytotoxicactivity,whereassolubleFasLappearstopromoteautoimmunityandtumOrigenesisviainductionofnon-apoptoticpathways,inparticularNF-κB.
ProductReferences
- Monoclonalantibody-mediatedtumorregressionbyinductionofapoptosis:B.C.Trauth,etal.;Science245,301(1989)
- Monoclonal-antibody-mediatedapoptosisinadultT-cellleukaemia:K.M.Debatin,etal.;Lancet335,497(1990)
- Inductionofapoptosisbymonoclonalantibodyanti-APO-1classswitchvariantsisdependentoncross-linkingofAPO-1cellsurfaceantigens:J.Dhein,etal.;J.Immunol.149,3166(1992)
- APO-1-inducedapoptosisofleukemiacellsfrompatientswithadultT-cellleukemia:K.M.Debatin,etal.;Blood81,2972(1993)
- Theapoptosis-1/Fasproteininhumansystemiclupuserythematosus:E.Mysler,etal.;J.Clin.Invest.93,1029(1994)
- InhibitionofapoptosisinTcellsexpressinghumanTcellleukemiavirustypeITax:K.F.Copeland,etal.;AIDSRes.Hum.Retroviruses10,1259(1994)
- ActivationinducessensitivitytowardAPO-1(CD95)-mediatedapoptosisinhumanBcells:P.T.Daniel&P.H.Krammer;J.Immunol.152,5624(1994)
- APO-1(CD95)mediatedapoptosisinhumanT-ALLengraftedinSCIDmice:K.M.Lücking-Famira,etal.;Leukemia8,1825(1994)
- Apoptoticcelldeathinducedbyamouse-humananti-APO-1chimericantibodyleadstotumorregression:L.R.Coney,etal.;Int.J.Cancer58,562(1994)
- CellnucleusandDNAfragmentationarenotrequiredforapoptosis:K.Schulze-Osthoff,etal.;J.CellBiol.127,15(1994)
- DivergentsignallingviaAPO-1/FasandtheTNFreceptor,twohomologousmoleculesinvolvedinphysiologicalcelldeath:K.Schulze-Osthoff,etal.;EMBOJ.13,4587(1994)
- AutocrineT-cellsuicidemediatedbyAPO-1/(Fas/CD95):J.Dhein,etal.;Nature373,438(1995)
- CD40ligationinducesApo-1/FasexpressiononhumanBlymphocytesandfacilitatesapoptosisthroughtheApo-1/Faspathway:E.J.Schattner,etal.;J.Exp.Med.182,1557(1995)
- Cytotoxicity-dependentAPO-1(Fas/CD95)-associatedproteinsformadeath-inducingsignalingcomplex(DISC)withthereceptor:F.C.Kischkel,etal.;EMBOJ.14,5579(1995)
- ResistancetoAPO-1(CD95)inducedapoptosisinT-ALLisdeterminedbyaBCL-2independentanti-apoptoticprogram:K.M.Debatin&P.H.Krammer;Leukemia9,815(1995)
- SensitizationofTcellstoCD95-mediatedapoptosisbyHIV-1Tatandgp120:M.O.Westendorp,etal.;Nature375,497(1995)
- Themedicalsignificanceofphysiologicalcelldeath:G.Hacker&D.L.Vaux;Med.Res.Rev.15,299(1995)
- InvolvementoftheCD95(APO-1/FAS)receptor/ligandsystemindrug-inducedapoptosisinleukemiacells:C.Friesen,etal.;Nat.Med.2,574(1996)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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