![Adipogen/anti-Dityrosine [DT], mAb (1C3)/JAI-MDT-020P/20 µg](https://www.ebiomall.cn/images/adipogen/adipogen_logo_bw_2.png){kind=logo}
Adipogen/anti-Dityrosine [DT], mAb (1C3)/JAI-MDT-020P/20 µg
商品编号：
JAI-MDT-020P
品牌：
Adipogen Inc
市场价：
¥4600.00
美元价：
2760.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 1C3 |
| Isotype | MouseIgG2aκ |
| Immunogen/Antigen | 3-(p-hydroxyphenyl)propionicaciddimer-conjugatedkeyholelimpethemocyanin. |
| Application | ELISA Immunohistochemistry:Recommendedconcentrationis1-5μg/mL WesternBlot |
| Crossreactivity | All Human |
| Specificity | Recognizesfreedityrosine,3-(p-hydroxyphenyl)propionicaciddimer,dityrosine-BSAconjugate,anddityrosineinproteinorpeptides.Doesnotcross-reactwithnitrotyrosine,chlorotyrosine,aminotyrosine,phosphotyrosine,tyrosine,3-(p-hydroxyphenyl)propionicacid,phenylalanine,3,4-dihydroxyphenylaceticacid(DOPA). |
| PurityDetail | ProteinApurified. |
| Formulation | Lyophilized.Contains10mMPBS(pH7.4). |
| Reconstitution | Reconstitutewith200μLdistilledwater. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyJaICA. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Tyrosineisoneofthemajortargetsofproteinoxidation.Dityrosine(DT)isknowntobeformedwhentyrosineisdamagedbyfreerADIcals,suchasreactiveoxygenspecies(ROS),metal-catalyzedoxidation,ultravioletirradiation,andperoxidases.Dityrosinehasbeenfoundinatheroscleroticlesions,andlipofuscinofpyramidalneuronsofagedhumanbrains.DityrosineisaspecificbioMarkerforproteinoxidation.Dityrosineisreportedtoexistinvarioustissuesandwasalsorecentlydetectedinurinesamples.Itisexpectedtobeanovelproteinoxdationmarker,whichisnon-invasivelydetectable.
ProductReferences
- Immunochemicaldetectionofproteindityrosineinatheroscleroticlesionofapo-E-deficientmiceusinganovelmonoclonalantibody:Y.Kato,etal.;BBRC275,11(2000)
- Thehydrogenperoxide/copperionsystem,butnotothermetal-catalyzedoxidationsystems,producesprotein-bounddityrosine:Y.Kato,etal.;FreeRadic.Biol.Med.31,624(2001)
- Coppermediatesdityrosinecross-linkingofAlzheimer’samyloid-beta:C.S.Atwood,etal.;Biochemistry43,560(2004)
- Immunohistochemicaldetectionofoxidativestressbiomarkers,dityrosineandN(epsilon)-(hexanoyl)lysine,andC-reactiveproteininrabbitatheroscleroticlesions:Y.Fukuchi,etal.;J.Atheroscler.Thromb.15,185(2008)
- Expressionsofproteinoxidationmarkers,dityrosineandadvancedoxidationproteinproductsinCisplatin-inducednephrotoxicityinrats:Y.Kimoto,etal.;J.Vet.Med.Sci.73,403(2011)
- Effectofproteinmalnutritionontheskinepidermisofhairlessmice:A.Sugiyama,etal.;J.Vet.Med.Sci.73,831(2011)
- Expressionsofproteinoxidationmarkers,dityrosineandadvancedoxidationproteinproductsinacetaminophen-inducedliverinjuryinrats:J.Sun,etal.;J.Vet.Med.Sci.73,1185(2011)
- Intramolecularcross-linkinginthenativeJHBPmolecule:D.Bystranowska,etal.;Arch.Biochem.Biophys.517,12(2012)
- Di-tyrosinecross-linkdecreasesthecollisionalcross-sectionofAbpeptidedimersandtrimersinthegasphase:Anionmobilitystudy:E.Sitkiewicz,etal.;PLOSOne9,e100200(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
