脂肪原/抗Cofilin，单克隆抗体（AF2C2）/YIF-LF-MA0296/100µl
商品编号：
YIF-LF-MA0296
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | CFL; p18; CFL1; Cofilin-1; 18 kDa Phosphoprotein; Cofilin; Non-muscle Isoform |
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | AF2C2 |
| Isotype | Mouse IgG2a κ |
| Immunogen/Antigen | Recombinant human His-cofilin protein purified from E. coli. |
| Application |
ELISA Western Blot (1:2,000) |
| Crossreactivity |
Human Mouse Rat |
| Purity Detail | Ammonium sulfate precipitation. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Cofilin belongs to a family of related proteins with similar biochemical activities called the actin depolymerizing factor (ADF)/cofilin family. ADF/cofilins play an important role in cytokinesis , endocytosis, and in the development of all embryonic tissues. Cofilin is a small ubiquitous protein (~19 kDa) that is able to bind both G-actin (monomeric) and F-actin(filamentous actin). Cofilin promotes the regeneration of actin filaments by severing pre-existing filaments. LIMK or TESK play a central role in the regulation of the actin cytoskeleton by phosphorylating cofilin on Ser3. Phosphorylation of cofilin at Ser3 inhibits its ability to bind to actin. Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.
Product References
1) Wang W, Eddy R, Condeelis J, (2007) Nat Rev Cancer 7(6):429-40. (General)
2) Condeelis, J, (2001) Trends Cell Biol 11, 288-293. (General)
3) Scott RW and Olson MF, (2007) J Mol Med 85(6):555-68. (General)
2) Condeelis, J, (2001) Trends Cell Biol 11, 288-293. (General)
3) Scott RW and Olson MF, (2007) J Mol Med 85(6):555-68. (General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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