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Adipogen/anti-Chk1 (Checkpoint Kinase 1), pAb/YIF-LF-PA0059/100 µl
Adipogen/anti-Chk1 (Checkpoint Kinase 1), pAb/YIF-LF-PA0059/100 µl
商品编号：
YIF-LF-PA0059
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CHK1;CHEK1;EC=2.7.11.1;CheckpointKinase-1;CHK1CheckpointHomolog;CellCycleCheckpointKinase;Serine/Threonine-ProteinKinaseChk1 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Immunogen/Antigen | Syntheticpeptide. |
| Application | WesternBlot(1:2,000) Immunoprecipitationnottested. |
| Crossreactivity | Human |
| PurityDetail | ProteinApurified. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Checkpointkinase1(Chk1)isaserine/threonineproteinkinaseandakeymediatorintheDNAdamage-inducedcheckpointnetwork.Chk1isanevolutionarilyconservedproteinkinasethatfunctionstoensuregenomicintegrityupongenotoxicstress.WhentheG2orScheckpointisabrogatedbytheinhibitionofChk1,p53-deficientcancercellsundergomitoticcatastropheandeventuallyapoptosis,whereasnormalcellsarestillarrestedintheG1phase.Thus,Chk1inhibitorscanpreferentiallypotentiatetheefficacyofDNAdamagingagentsincancercells,andChk1isanattractivetherapeutictargetforcancertreatment,especiallysinceapproximately50%ofallhumancancersarep53-deficient.RequiredforcheckpointmediatedcellcyclearrestinresponsetoDNAdamageorthepresenceofunreplicatedDNA.Mayalsonegativelyregulatecellcycleprogressionduringunperturbedcellcycles.Recognizesthesubstrateconsensussequence[R-X-X-S/T].BindstoandphosphorylatesCDC25A,CDC25BandCDC25C.PhosphorylationofCDC25Aat"Ser-178"and"Thr-507"andphosphorylationofCDC25Cat"Ser-216"createsbindingsitesfor14-3-3proteinswhichinhibitCDC25AandCDC25C.PhosphorylationofCDC25Aat"Ser-76","Ser-124","Ser-178","Ser-279"and"Ser-293"promotesproteolysisofCDC25A.InhibitionofCDC25activityleadstoincreasedinhibitorytyrosinephosphorylationofCDK-cyclincomplexesandblockscellcycleprogression.BindstoandphosphorylatesRAD51at"Thr-309",whichmayenhancetheassociationofRAD51withchromatinandpromoteDNArepairbyhomologousrecombination.BindstoandphosphorylatesTLK1at"Ser-743",whichpreventstheTLK1-dependentphosphorylationofthechromatinassemblyfactorASF1A.ThismayaffectchromatinassemblyduringSphaseorDNArepair.MayalsophosphorylatemultiplesiteswithintheC-terminusofTP53,whichpromotesactivationofTP53byacetylationandenhancessuppressionofcellularproliferation.
ProductReferences
1)TaoZF,(2006),AnticancerAgentsMedChem6(4),377-88.(General)
2)ChenYandSanchezY,(2004),DNARepair(Amst)3(8-9),1025-32.(General)
3)SancarAetal.,(2004),AnnuRevBiochem73,39-85.(General)
4)BartekJandLukasJ,(2003),CancerCell3(5),421-9.(General)
2)ChenYandSanchezY,(2004),DNARepair(Amst)3(8-9),1025-32.(General)
3)SancarAetal.,(2004),AnnuRevBiochem73,39-85.(General)
4)BartekJandLukasJ,(2003),CancerCell3(5),421-9.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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