Adipogen/anti-CDK5, pAb/YIF-LF-PA0222/100 µl
商品编号：
YIF-LF-PA0222
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | CDK5; CDKN5; EC=2.7.11.22; TPKII Catalytic Subunit; Cyclin-dependent Kinase 5; Cell Division Protein Kinase 5; Tau Protein Kinase II Catalytic Subunit; Serine/Threonine-Protein Kinase PSSALRE |
| Product Type | Polyclonal Antibody |
| Properties | |
| Immunogen/Antigen | Recombinant human His-CDK5 protein purified from Baculovirus expressed insect cells. |
| Application | Western Blot (1:500~1,000) |
| Crossreactivity |
Human Mouse Rat |
| Purity Detail | Protein A purified. |
| Formulation | Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Declaration | Manufactured by AbFrontier |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Cyclin-dependent kinase-5 (CDK5) is a member of the cyclin-dependent kinase family of serine/threonine kinases. Its mRNA and protein are expressed in the kidneys, testes, and ovaries. And Its activity has been detected almost exclusively in brain extracts. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity; however, Cdk5 is not activated by cyclins. Instead, Cdk5 activity requires association with one of two brain-specific regulatory subunits, called p35 and p39. These two activators regulate the spatial and temporal expression of active Cdk5, restricting its activity primarily to post-mitotic neurons. Probably involved in the control of the cell cycle. Interacts with D1 and D3-type G1 cyclins. Can phosphorylate histone H1, tau, MAP2 and NF-H and NF-M. Also interacts with p35 which activates the kinase.
Product References
1) Shirley B. Shelton and Gail V.W. Johnson (2004) Journal of Neurlchemistry 88,1313-1326. (General)
2) Jonathan C Cruz and Li-Huei Tsai (2004) Current Poinion in Neurobiology 14:390-394. (General)
3) Deanna S. Smith, et al. (2001) Cell Growth & Differentiation 12,277-283. (General)
2) Jonathan C Cruz and Li-Huei Tsai (2004) Current Poinion in Neurobiology 14:390-394. (General)
3) Deanna S. Smith, et al. (2001) Cell Growth & Differentiation 12,277-283. (General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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