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Adipogen/anti-CD40 (mouse), mAb (FGK45) (preservative free)/AG-20B-0036PF-C500/500 µg
Adipogen/anti-CD40 (mouse), mAb (FGK45) (preservative free)/AG-20B-0036PF-C500/500 µg
商品编号：
AG-20B-0036PF-C500
品牌：
Adipogen Inc
市场价：
¥7600.00
美元价：
4560.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TumorNecrosisFactorReceptorSuperfamilyMember5;CD40LReceptor |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | FGK45 |
| Isotype | RatIgG2a |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | RecombinantmouseCD40fusionprotein. |
| Application | FlowCytometry FunctionalApplication:ActivatesBandNKcellsinvivoandinvitro. |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseCD40. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| EndotoxinContent | <0.01eu g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBS. |
| OtherProductData | WidelyusedstimulatoryMAbtoCD40.Showntoindirectlyactivatenaturalkiller(NK)cells,producingsignificantantitumorandantimetastaticeffects.Effectiveinboostingimmuneresponsesagainstinfectiousagentsandcanpotentiallybeusedtotreatchronicautoimmuneinflammatoryprocesses. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
CD40belongstotheTNF-receptorsuperfamilyandisessentialinmediatingabroadvarietyofimmuneandinflammatoryresponsesincludingTcell-dependentimmunoglobulinclassswitching,memoryBcelldevelopment,andgerminalcenterformation.TheinteractionofCD40-CD40Lisnecessaryforamyloid-beta-inducedmicroglialactivation,andthusisthoughttobeanearlyeventinAlzheimerdiseasepathogenesis.CD40isconstitutivelyexpressedbyantigenpresentingcells,includingdendriticcells,Bcellsandmacrophages.Consistentwithitswidespreadexpressiononnormalcells,CD40isalsoexpressedonawiderangeoftumorcells,includingnon-Hodgkin"sandHodgkin"slymphomas,myelomaandsomecarcinomasincludingnasopharynx,bladder,cervix,kidneyandovary.
ProductReferences
- TheSCIDbutnottheRAG-2geneproductisrequiredforSmu-Sepsilonheavychainclassswitching:A.ROlink,etal.;Immunity5,319(1996)
- CharacterizationofimmatureBcellsbyanovelmonoclonalantibody,byturnoverandbymitogenreactivity:A.G.Rolink,etal.;Eur.J.Immunol.28,3738(1998)
- Anti-CD40antibodyinducesantitumorandantimetastaticeffects:theroleofNKcells:J.G.Turner,etal.;J.Immunol.166,89(2001)
- TherapeuticactivityofagoNISTicmonoclonalantibodiesagainstCD40inachronicautoimmuneinflammatoryprocess:C.Mauri,etal.;Nat.Med.6,673(2000)
- Ovarianinsufficiencyandearlypregnancylossinducedbyactivationoftheinnateimmunesystem:A.Erlebacher,etal.;J.Clin.Invest.114,39(2004)
- CD154isanegativeregulatorofautoaggressiveCD8+Tcellsintype1diabetes:C.M.McGregor,etal.;PNAS101,9345(2004)
- IRF-7isthemasterregulatoroftype-Iinterferon-dependentimmuneresponses:K.Honda,etal.;Nature434,772(2005)
- InvivoandinvitroregulationoftypeIIFNsynthesisbysynergisticeffectsofCD40andtypeIIIFN:J.A.Greene,etal.;J.Immunol.176,5995(2006)
- IL-10-andIL-12-independentdown-regulationofallergicsensitizationbystimulationofCD40signaling:P.W.Hellings,etal.;J.Immunol.177,5138(2006)
- AgonisticAnti-CD40AntibodyProfoundlySuppressestheImmuneResponsetoInfectionwithLymphocyticChoriomeningitisVirus:C.Bartholdy,etal.;J.Immunol.178,1662(2007)
- Excessiveinterferon-αsignalinginautoimmunityaltersglycosphingolipidprocessinginBcells:A.Hee-MengTan,etal.;J.Autoimmun.inpress(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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