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Adipogen/anti-CD112R (mouse), pAb (IN109)/AG-25B-0035-C100/100 µg
Adipogen/anti-CD112R (mouse), pAb (IN109)/AG-25B-0035-C100/100 µg
商品编号：
AG-25B-0035-C100
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CD112Receptor;PoliovirusReceptor-relatedImmunoglobulinDomain-containingProtein;TransmembraneProteinPVRIG |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | RecombinantmouseCD112R. |
| Application | WesternBlot:(1:1"000) ELISA:(1:2"000) |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseCD112R.Doesnotcross-reactwithhumanCD112R. |
| PurityDetail | ProteinAaffinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD112(alsocalledNectin-2orpoliovirusreceptor-related2protein)isatypeItransmembraneglycoproteinandamemberoftheIggenesuperfamily(IGSF).CD112/Nectin-2functionsasanadhesionmoleculeinvolvedintheformationofcelljunctionsandinteractionswithotherNectin-familymolecules.Nectin-2isaalsoasurfaceMarkerofsomeendothelialcellsandregulatesmigration,proliferationandangiogenesis.CD112functionsasanimmunecheckpointregulatorbymodulatingTcellsignaling,eitherasacostimulatorofTcellfunction,orasacoinhibitorofTcellsproliferationbybindingtothereceptorsCD226orTIGIT(TcellIgandimmunoreceptortyrosine-basedinhibitorymotif(ITIM)domain),respectively.ThebindingofCD112ligandtothesereceptorsisweakcomparedtoCD155.Recently,anewreceptorofCD112,calledCD112RorPVRIG(Poliovirusreceptor-relatedimmunoglobulindomain-containingprotein)hasbeencharacterized,showinghighaffinitytoCD112.CD112RisanewcoinhibitoryreceptorofthePVRfamilyforhumanTcells,inhibitingTCR-mediatedsignalsuponbindingtoCD112/Nectin-2.CD112RispreferentiallyexpressedinTlymphocytesandNKcells.CancercellsevadeimmuneresponsesasaresultofanimmunosuppressivetumormicroenvironmentandCD112R,byplayingaroleintheregulationoftheimmunesystem,couldbeanewattractivecancerimmunotherapytarget.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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