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Adipogen/anti-Caspase-8 (mouse), mAb (1G12)/AG-20T-0137-C100/100 µg
Adipogen/anti-Caspase-8 (mouse), mAb (1G12)/AG-20T-0137-C100/100 µg
商品编号：
AG-20T-0137-C100
品牌：
Adipogen Inc
市场价：
¥5800.00
美元价：
3480.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ApoptoticCysteineProtease;ApoptoticProteaseMch-5;CAP4;FADD-homologousICE/ced-3-likeProtease |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 1G12 |
| Isotype | RatIgG1κ |
| Immunogen/Antigen | Recombinantmousecaspase-8(p20subunit). |
| Application | ELISA:(recombinantmousecaspase-8) FlowCytometry:(overexpressedincelllines) Immunocytochemistry:(seeliteraturereference2) WesternBlot:(excellent) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Mouse |
| Specificity | Recognizesthep20subunitofmousecaspase-8.Detectsbandsof~55kDa(full-lengthcaspase-8)and~18kDa(apoptosis-inducedcleavagefragment)byWesternblot.Doesnotcross-reactwithhumancaspase-8. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified(sepharosecolumn). |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Procaspase-8belongstothefamilyofcaspases.BindingofFasLtoFasleadstoformationofareceptorcomplexatthecellularmembrane,whichwasnamedDISC.TheDISCconsistsofoligomerizedreceptors,theDD-containingadaptormoleculeFADD,procaspase-8,procaspase-10andc-FLIP.TheDISCstructureprovidesaplatformfortheoligomerizationofprocaspase-8thatallowstwoprocaspase-8homodimerstobeinthecloseproximityleADIngtotheinitialactivationofprocaspase-8.Atthefirstcleavagestep,theN-terminalp43/p41andtheC-terminalp30cleavageproductsaregenerated.Importantly,thesecleavageproductsalreadypossesscatalyticactivity.Atthesecondcleavagestep,p43/p41andp30areprocessedtop10andp20,respectively,whichleadstothegenerationoftheactivecaspase-8heterotetramer(p20/p10)2.
ProductReferences
- Apaf-1andcaspase-9donotactastumorsuppressorsinmyc-inducedlymphomagenesisormouseembryofibroblasttransformation:C.L.Scott,etal.;J.CellBiol.164,89(2004)
- ModificationsandintracellulartraffickingofFADD/MORT1andcaspase-8afterstimulationofTlymphocytes:L.A.O"Reilly,etal.;CellDeathDiffer.11,724(2004)
- Caspase-8servesbothapoptoticandnonapoptoticroles:T.B.Kang,etal.;J.Immunol.73,2976(2004)
- RoleofmembranesphingomyelinandceramideinplatformformationforFas-mediatedapoptosis:M.Miyaji,etal.;J.Exp.Med.202,249(2005)
- FatalHepatitisMediatedbyTumorNecrosisFactorTNFαRequiresCaspase-8andInvolvestheBH3-OnlyProteinsBidandBim:T.Kaufmann,etal.;Immunity30,56(2009)
- Catalyticactivityofthecaspase-8-FLIPLcomplexinhibitsRIPK3-dependentnecrosis:A.Oberst,etal.;Nature471,363(2011)
- FLIP(Flice-likeinhibitoryprotein)suppressescytoplasmicdouble-stranded-RNA-inducedapoptosisandNF-BandIRF3-mediatedsignaling:P.Handa,etal.;CellCommun.Signal.9,16(2011)
- XIAPrestrictsTNF-andRIP3-dependentcelldeathandinflammasomeactivation:M.Yabal,etal.;CellRep.7,1796(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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