Adipogen/anti-Caspase-2, mAb (10C6)/AG-20T-0135-C100/100 µg
商品编号：
AG-20T-0135-C100
品牌：
Adipogen Inc
市场价：
¥6800.00
美元价：
4080.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CASP-2;ProteaseICH-1;NeuralPrecursorCellExpressedDevelopmentallyDown-regulatedProtein2;NEDD-2 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 10C6 |
| Isotype | RatIgG2aκ |
| Immunogen/Antigen | Recombinanthumancaspase-2(p19subunit). |
| Application | ELISA FlowCytometry:(overexpressedincelllines) Immunocytochemistry:(10-20μg/ml;fixin4%paraformaldehyde,0.18%Triton-X100for10min.priortostaining) Immunohistochemistry:(frozensections) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Dog Human Monkey Mouse Rat |
| Specificity | Recognizesanepitopeinthep19subunitofhuman,mouse,rat,monkeyanddogcaspase-2. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified(sepharosecolumn). |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Caspase-2isaClassIcaspasewithalongprodomainnecessaryfornuclearlocalization.Uponactivationoftheapoptoticpathway,theprocaspaseiscleavedintosmallerfragments.Caspase-2isthenuclearapoptoticrespondenttocellulargenotoxicstressormitoticcatastropheandisinvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Activationoccursuponrecruitmenttoacomplexcontainingap53-induceddeathdomainprotein,PIDD.Thissuggestscaspase-2canbeanuclearinitiatorcaspasewitharequirementforcaspase-9andcaspase-3activationindownstreamapoptoticevents.InapoptoticpathwaysresultingfromUV-inducedDNAdamage,processingofcaspase-2occursdownstreamofmitochondrialdysfunctionandofcaspase-9andcaspase-3activation,extendingapossibleroleforcaspase-2asaparalleleffectorcaspase.
ProductReferences
- Caspase-2isnotrequiredforthymocyteorneuronalapoptosiseventhoughcleavageofcaspase-2isdependentonbothApaf-1andcaspase-9:L.A.O"Reilly,etal.;CellDeathDiffer.9,832(2002)
- Apaf-1andcaspase-9donotactastumorsuppressorsinmyc-inducedlymphomagenesisormouseembryofibroblasttransformation:C.L.Scott,etal.;J.CellBiol.164,89(2004)
- Apaf-1andcaspase-9arerequiredforcytokinewithdrawal-inducedapoptosisofmastcellsbutdispensablefortheirfunctionalandclonogenicdeath:V.S.Marsden,etal.;Blood107,1872(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
