当前位置：
首页
>
产品中心 >
Functional_antibody >
Adipogen/anti-Calretinin (Calbindin-2), mAb (AF5D11)/YIF-LF-MA0346/100 µl
Adipogen/anti-Calretinin (Calbindin-2), mAb (AF5D11)/YIF-LF-MA0346/100 µl
商品编号：
YIF-LF-MA0346
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CR;CALB2;CAB29;Calretinin;29kDaCalbindin |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | AF5D11 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-Calbindin2proteinpurifiedfromE.coli. |
| Application | WesternBlot(1:1,000) |
| Crossreactivity | Human Mouse |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Calciumbindingproteins(CBPs)regulateintracellularlevelsofcalciumCa2+ions.CBPsareinvolvedinnumerousfunctions,suchascellsignaling,calciumuptakeandtransport,andcellmotility.Calretinin(CR),calbindinD-28k(CB)andparvalbumin(PV)belongtothelargefamilyofEfhandcalcium-bindingproteins.TheEF-handisanaminoacidsequencewithaharacteristicthreedimensionalhelix-loop-helixstructurewithhighaffinityforCa2+.CalbindinD28k(calbindin)isahexaEF-handproteinof261residueswith59%sequenceidentitytocalretinin.Itisasingle-domainproteinandthesixEFhandsinteractextensivelywithoneanothersothattheyformonelargeglobulardomain.Calbindinisfoundinthebrainandcentralnervoussystemwithadistinctdistributionovercertainneuronalsubtypes.Neuroprotectiveeffectsofcalbindinhasbeenreportedinischemicandglutamatetoxicitymodels,primarilyduetoitsabilitytochelatecalcium.MicelackingcalbindinhavebeenshowntosufferfromimpairedmotorcoordinationduetoalteredneuronalCa2+-homeostasis.Notably,calbindinisfoundinhighconcentrationinthekidneyandinpancreaticβ-cells,whereithasbeenshowntoprotectagainstapoptosis.Inosteoblasts,anti-apopticactivityofcalbindinthroughthebindingtocaspase-3hasalsobeenreported.Calbindinprotectsagainstapoptoticandnecroticcelldeath,suggestingitsabilitytobuffercalcium.CalbindinhasbeenreportedtobindsZn2+,revealingnegativeallostericeffectbetweentheZn2+-andCa2+-bindingevents.Calretininisacalcium-bindingproteinwhichisabundantinauditoryneurons.
ProductReferences
1)BauerMCetal.,(2008)ProteinSci17(4):760-767.(General)
2)AnelliRandHeckmanCJ,(2005)JNeurocytol34(6):369-385.(General)
3)LinseSetal.,(1997)ProteinSci6(11):2385-2396.(General)
2)AnelliRandHeckmanCJ,(2005)JNeurocytol34(6):369-385.(General)
3)LinseSetal.,(1997)ProteinSci6(11):2385-2396.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
