Adipogen/anti-ATM, mAb (9A2)/YIF-LF-MA0254/100 µl
商品编号：
YIF-LF-MA0254
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ATM;EC=2.7.11.1;A-TMutated;Serine-ProteinKinaseATM;AtaxiaTelangiectasiaMutated |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 9A2 |
| Isotype | MouseIgG2bκ |
| Immunogen/Antigen | RecombinanthumanHis-ATM(aa2841-3056)proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) Immunoprecipitation(1μl) |
| Crossreactivity | Human |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ataxiatelangiectasiamutated(ATM)isaserine/threonine-specificproteinkinasethatisactivatedbyDNAdouble-strandbreaks.ItphosphorylatesseveralkeyproteinsthatinitiateactivationoftheDNAdamagecheckpoint,leADIngtocellcyclearrest,DNArepairorapoptosis.Severalofthesetargetsarep53,CHK2,BRCA1,andH2AX.ATMtriggerstheG1/Scheckpoint;ATR(AtaxiatelangiectasiaandRad3-related)preventsG1/Sstasis.Inthissinglepointinthecellcycle,itwouldappearthatATMandATRfunctioninoppositiontooneanother.Ataxiatelangiectasia(AT)isarareneurodegenerative,autosomalrecessivedisordercharacterizedbychromosomeinstability,radiosensitivity,immunodeficiencyandapredispositionforcancer.TheATR(ATMandRad3-related)kinaseanditsdownstreameffectorkinase,Chk1,arecentralregulatorsofthereplicationcheckpoint.Lossofthesecheckpointproteinscausesreplicationforkcollapseandchromosomalrearrangements.ATRarethoughttobemastercontrollersofcellcyclecheckpointsignalingpathwaysthatarerequiredforcellresponsetoDNAdamageandforgenomestability.Serine/threonineproteinkinasewhichactivatescheckpointsignalingupondoublestrandbreaks(DSBs),apoptosisandgenotoxicstressessuchasionizingultravioletAlight(UVA),therebyactingasaDNAdamagesensor.Recognizesthesubstrateconsensussequence[ST]-Q.Phosphorylates"Ser-139"ofhistonevariantH2AX/H2AFXatdoublestrandbreaks(DSBs),therebyregulatingDNAdamageresponsemechanism.Alsoinvolvedinsignaltransductionandcellcyclecontrol.Mayfunctionasatumorsuppressor.NecessaryforactivationofABL1andSAPK.Phosphorylatesp53/TP53,FANCD2,NFKBIA,BRCA1,CTIP,nibrin(NBN),TERF1,RAD9andDCLRE1C.Mayplayaroleinvesicleand/orproteintransport.CouldplayaroleinT-celldevelopment,gonadandneurologicalfunction.Playsaroleinreplication-dependenthistonemRNAdegradation.BindsDNAends.
ProductReferences
1)PaulsenRDandCimprichKA.(2007),DNARepair(Amst)6(7):953-966.(General)
2)HurleyPJandBunzF.(2007),CellCycle.6(4):414-417.(General)
3)KurzEUandLees-MillerSP,(2005),DNARepair(Amst)3(8-9):889-900.(General)
2)HurleyPJandBunzF.(2007),CellCycle.6(4):414-417.(General)
3)KurzEUandLees-MillerSP,(2005),DNARepair(Amst)3(8-9):889-900.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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