脂肪原/抗Asc，pAb（AL177）/AG-25B-0006-C100/100µg
商品编号：
AG-25B-0006-C100
品牌：
Adipogen Inc
市场价：
¥8000.00
美元价：
4800.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Pycard;TargetofMethylation-inducedSilencing1;TMS1;CaspaseRecruitmentDomain-containingProtein5;Apoptosis-associatedSpeck-likeProteinContainingCARD;CARD5 |
| ProductType | PolyclonalAntibody |
| Properties | |
| Source/Host | Rabbit |
| Immunogen/Antigen | SyntheticpeptidecorrespondingtoaaattheN-terminalhumanAsc. |
| Application | Immunocytochemistry(1:200) Immunohistochemistry:(1:500;paraffinsections) Immunoprecipitation:(1:200) WesternBlot:(1:1000) FunctionalApplication:(see[1]) |
| Crossreactivity | Human Mouse |
| Specificity | RecognizeshumanandmouseAsc. |
| PurityDetail | Epitope-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Ascpromotescaspase-mediatedapoptosis.Thisproapoptoticactivityismediatedpredominantlythroughtheactivationofcaspase-9.Itisacomponentoftheinflammasome,aproteincomplexwhichalsoincludesNLRP3/NALP3,CARD8andCASP1andwhosefunctionistheactivationofproinflammatorycaspases.
ProductReferences
- NALP3formsanIL-1beta-processinginflammasomewithincreasedactivityinMuckle-Wellsautoinflammatorydisorder:L.Agostini,etal.;Immunity20,319(2004)
- P2X7ReceptorDifferentiallyCouplestoDistinctReleasePathwaysforIL-1betainMouseMacrophage:P.Pelegrin,etal.;J.Immunol.180,7147(2008)
- InflammatoryroleofASCinantigen-inducedarthritisisindependentofcaspase-1,NALP-3,andIPAF:L.Kolly,etal.;J.Immunol.183,4003(2009)
- ActivationofautophagybyinflammatorysignalslimitsIL-1bproductionbytargetingubiquitinatedinflammasomesfordestruction:C.-S.Shi,etal.;Nat.Immunol.13,255(2012)
- NLRP3isactivatedinAlzheimer"sdiseaseandcontributestopathologyinAPP/PS1mice:M.T.Heneka,etal.;Nature493,674(2013)
- Promyelocyticleukemiaproteininteractswiththeapoptosis-associatedspeck-likeproteintolimitinflammasomeactivation:J.K.Dowling,etal.;J.Biol.Chem.289,6429(2014)
- Localizationandfunctionalityoftheinflammasomeinneutrophils:M.Bakele,etal.;J.Biol.Chem.289,5320(2014)
- TheadaptorASChasextracellularand"prionoid"activitiesthatpropagateinflammation:B.S.Franklin,etal.;Nat.Immunol.15,727(2014)
- TheNLRP3inflammasomeisreleasedasaparticulatedangersignalthatamplifiestheinflammatoryresponse:A.Baroja-Mazo,etal.;Nat.Immunol.15,738(2014)
- Aging-associatedTNFproductionprimesinflammasomeactivationandNlrp3-relatedmetabolicdisturbances:F.Bauernfeind,etal.;J.Immunol.197,2900(2016)
- AnInvestigationofInflammatoryandMetabolicBlood-BasedBioMarkersofCognitiveDecline:H.Wolfe;ThesisUniv.Dublin,TrinityCollegeDep.ofPhysiol.(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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