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脂肪原/抗APRIL（小鼠），单克隆抗体（受体）（阻断）（Apry-1-1）（生物素）/AG-27B-0001B-C100/100µg
脂肪原/抗APRIL（小鼠），单克隆抗体（受体）（阻断）（Apry-1-1）（生物素）/AG-27B-0001B-C100/100µg
商品编号：
AG-27B-0001B-C100
品牌：
Adipogen Inc
市场价：
¥8200.00
美元价：
4920.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AProliferationInducingLigand;TNFSF13;CD256;TALL-2 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | Apry-1-1 |
| Isotype | MouseIgG2b&lamBDa; |
| Source/Host | Purifiedfrom HEK293cell culturesupernatant. |
| Immunogen/Antigen | MouseAPRIL(aa98-232). |
| Label/Conjugates | Biotin |
| Application | ELISA Immunoprecipitation:(1:200) Functional:InhibitsthebindingofmouseAPRILtoBCMAandTACI.ForadditionalinformationseeP.Haselmayer,etal.(2017)(Ref5). |
| Crossreactivity | Mouse |
| Specificity | RecognizesmouseAPRIL.DoesnotrecognizemouseBAFF. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal-test;="" lonza)=""> |
| Concentration | 0.5mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| OtherProductData | APRIL(mouse)monoclonalantibody(recombinant)(blocking)(APRY-1-1)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothemouselgG2bFcdomain. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1monthafterreceiptwhenstoredat+4°C. Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
APRILisacytokinethatbelongstotheTNFsuperfamilyandbindstoTACIandBCMA.Itisimplicatedintheregulationoftumorcellgrowthandisinvolvedinmonocyte/macrophage-mediatedimmunologicalprocesses.
Anti-APRIL(mouse)MonoclonalAntibody(recombinant)(Blocking)(APRY-1-1)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
Anti-APRIL(mouse)MonoclonalAntibody(recombinant)(Blocking)(APRY-1-1)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
ProductReferences
- Productionoftheplasma-cellsurvivalfactorAPRILpeaksinmyeloidprecursorcellsfromhumanbonemarrow:T.Matthes,etal.;Blood118,1838(2011)
- Pathogenicroleofaproliferation-inducingligand(APRIL)inmurineIgAnephropathy:Y.G.Kim,etal.;PLoSOne10,e0137044(2015)
- TheBcell-stimulatorycytokinesBLySandAPRILareelevatedinhumanperiodontitisandarerequiredforBcell-dependentbonelossinexperimentalmurineperiodontitis:T.Abe,etal.;J.Immunol.195,1427(2015)
- SplenicmarginalzonegranulocytesacquireanaccentuatedneutrophilB-cellhelperphenotypeinchroniclymphocyticleukemia:M.Gätjen,etal.;CancerRes.76,5253(2016)
- AmousemodelofsystemiclupuserythematosusrespondsbettertosolubleTACIthantosolubleBAFFR,correlatingwithdepletionofplasmacells:P.Haselmayer,etal.;Eur.J.Immunol.47,1075(2017)(+Supplement)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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