Adipogen/anti-Apaf-1, mAb (18H2)/AG-20T-0134-C100/100 µg
商品编号：
AG-20T-0134-C100
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | ApoptosisProtease-activatingFactor1 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 18H2 |
| Isotype | RatIgG2aκ |
| Immunogen/Antigen | RecombinantmouseApaf-1(aa1-97)containingtheN-terminalCARDdomain. |
| Application | ELISA Immunocytochemistry Immunoprecipitation:(1:1000-1:2000) WesternBlot:(1:1000-1:2000) Optimalconditionsmustbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human Mouse |
| Specificity | RecognizestheCARDdomainofhumanandmouseApaf-1.Doesnotcross-reactwithratApaf-1. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| EndotoxinContent | <0.1eu mu;g="" purified="" protein="" (lal="" test;="" lonza).=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Apaf-1isacytoplasmicproteinthatformsoneofthecentralhubsintheapoptosisregulatorynetwork.Itcontains(fromtheNterminal)acaspaserecruitmentdomain(CARD),anATPasedomain(NB-ARC),fewshorthelicaldomainsandthenseveralcopiesoftheWD40repeatdomain.UponbindingcytochromecanddATP,thisproteinformsanoligomericapoptosome,mediatesthecytochromec-dependentautocatalyticactivationofpro-caspase-9(Apaf-3),leADIngtotheactivationofcaspase-3andapoptosis.
ProductReferences
- Apaf-1isatranscriptionaltargetforE2Fandp53:M.C.Moroni,etal.;Nat.CellBiol.3,552(2001)
- Apocytochromecblockscaspase-9activationandBax-inducedapoptosis:A.G.Martin&H.O.Fearnhead;J.Biol.Chem.277,50834(2002)
- Apaf-1andcaspase-9accelerateapoptosis,butdonotdeterminewhetherfactor-deprivedordrug-treatedcellsdie:P.G.Ekert,etal.;J.Cell.Biol.165,835(2004)
- IsApaf-1expressionfrequentlyabrogatedinmelanoma?:J.D.Allen,etal.;CellDeathDiffer.12,680(2005)
- TheDNArepaircomplexKu70/86modulatesApaf1expressionuponDNAdamage:D.DeZio,etal.;CellDeathDiffer.18,516(2011)
- ApoptosomeformationuponoverexpressionofnativeandtruncatedApaf-1incellfreeandcell-basedsystems:A.R.Noori,etal.;Arch.Biochem.Biophys.,aheadofprint(2018)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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