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Adipogen/anti-ANGPTL4 (coiled-coil domain) (human), mAb (Kairos4-397G)/AG-20A-0047-C050/50 µg
Adipogen/anti-ANGPTL4 (coiled-coil domain) (human), mAb (Kairos4-397G)/AG-20A-0047-C050/50 µg
商品编号：
AG-20A-0047-C050
品牌：
Adipogen Inc
市场价：
¥3600.00
美元价：
2160.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Angiopoietin-likeProtein4;FIAF;Fasting-inducedADIposeFactor;HFARP;HepaticFibrinogen/Angiopoietin-relatedProtein |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | Kairos4-397G |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | Recombinanthumancoiled-coildomainofANGPTL4. |
| Application | ELISA:(directorindirect:1:500-1:5"000) Immunohistochemistry:(10μg/ml) Westernblot:(1:500-1:5"000usingECL.SuggestedblockinganddilutionbufferisPBSTwith0.05%Tween20and5%skimmilk.Suggestedincubationtimeis1houratroomtemperature). Optimalconditionsshouldbedeterminedindividuallyforeachapplication. |
| Crossreactivity | Human |
| Specificity | Recognizesthecoiled-coildomain(CCD)ofhumanANGPTL4.Detectsabandof~19kDabyWesternblot. |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.0.2μm-filteredsolutioninPBS,pH7.4.Containsnopreservatives. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ANGPTL4mainlyexpressedinendothelialcells(hypoxia-induced).Regulatesangiogenesisandmodulatestumorgenesisanddirectlyregulateslipid,glucose,andenergymetabolism.Inhibitsproliferation,migration,andtubuleformationofendothelialcellsandreducesvascularleakage.ANGPTL4isaproteinconsistingofanN-terminalcoiled-coildomainandaC-terminalfibrinogen-likedomain(FLD).BothdomainshavedistinctBIOLOGicalfunctions.Thecoiled-coildomainisresponsIBLefortheinhibitoryeffectsonlipoproteinlipase(LPL)convertingtheactiveformofLPLintoaninactiveform,andtheFLDdomainmediatesitsantiangiogenicfunctions.ThecoiledcoilandtheFLDdomainsareseparatedbyashortlinkerthatcanbecleavedaftersecretion.ANGPTL4appearsonthecellsurfaceasthefull-lengthform,whereitcanbereleasedbyheparintreatment.ANGPTL4proteinisthenproteolyticallycleavedbyproproteinconvertases(PCs),includingfurin,PC5/6,pairedbasicaminoacid-cleavingenzyme4,andPC7.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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