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脂肪原/抗血管生成素-2（人），单克隆抗体（受体）（阻断）（Angy-1-4）（无防腐剂）/AG-27B-0015PF-M001/1 mg
脂肪原/抗血管生成素-2（人），单克隆抗体（受体）（阻断）（Angy-1-4）（无防腐剂）/AG-27B-0015PF-M001/1 mg
商品编号：
AG-27B-0015PF-M001
品牌：
Adipogen Inc
市场价：
¥34000.00
美元价：
20400.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ang-2;Ang2;Angpt2;Agpt2 |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | Angy-1-4 |
| Isotype | HumanIgG2&lamBDa;. |
| Source/Host | CHOcells |
| Immunogen/Antigen | Recombinanthumanangiopoietin-2. |
| Label/Conjugates | PreservativeFree |
| Application | ELISA Functional:Inhibitsthebindingofhumanangiopoietin-2tohumanTie-2.ND50*=600-800ng/ml(for10ng/mlofAngiopoietin-2) *ND50:50%neutralizingdoseofantibodyforagivenconcentrationofligand(herehumanAngiopoietin-2). |
| Crossreactivity | Human |
| Specificity | Recognizeshumanangiopoietin-2.Doesnotrecognizemouseangiopoietin-2andhumanangiopoietin-1. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinA-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glycerol |
| OtherProductData | anti-Angiopoietin-2(human),mAb(rec.)(blocking)(Angy-1-4)iscomposedofhumanvariableregions(VHandVL)(λ-chain)ofimmunoglobulinfusedtothehumanlgG2Fcdomain. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Angiopoietin-1(Ang-1)andAngiopoietin-2(Ang-2)arecloselyrelatedsecretedligandswhichbindwithsimilaraffinitytoTie-2.Tie-2andangiopoietinshavebeenshowntoplaycriticalrolesinembryogenicangiogenesisandinmaintainingtheintegrityoftheadultvasculature.Ang-1activatesTie-2signalingonendothelialcellstopromotechemotaxis,cellsurvival,cellsprouting,vesselgrowthandstabilization.Ang-2hasbeenidentifiedasasecretedproteinligandofTie-2andhasalternativelybeenreportedtobeanantagoNISTforAng-1inducedTie-2signalingaswellasanagonistforTie-2signaling,dependingonthecellcontext.
anti-Angiopoietin-2(human),mAb(rec.)(blocking)(Angy-1-4)(preservativefree)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
anti-Angiopoietin-2(human),mAb(rec.)(blocking)(Angy-1-4)(preservativefree)isanantibodydevelopedbyantibodyphagedisplaytechnologyusingahumannaiveantibodygenelibrary.TheselibrariesconsistofscFv(singlechainfragmentvariable)composedofVH(variabledomainofthehumanimmunoglobulinheavychain)andVL(variabledomainofthehumanimmunoglobulinlightchain)connectedbyapolypeptidelinker.Theantibodyfragmentsaredisplayedonthesurfaceoffilamentousbacteriophage(M13).ThisscFvwasselectedbyaffinityselectiononantigeninaprocesstermedpanning.Multipleroundsofpanningareperformedtoenrichforantigen-specificscFv-phage.Monoclonalantibodiesaresubsequentlyidentifiedbyscreeningaftereachroundofselection.TheselectedmonoclonalscFvisclonedintoanappropriatevectorcontainingaFcportionofinterestandthenproducedinmammaliancellstogenerateanIgGlikescFv-Fcfusionprotein.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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