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Adipogen/anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)/AG-27B-6003PF-C100/100 µg
Adipogen/anti-ADAM17 (human), mAb (rec.) (blocking) (D1(A12)) (Fab Fragment) (His)/AG-27B-6003PF-C100/100 µg
商品编号：
AG-27B-6003PF-C100
品牌：
Adipogen Inc
市场价：
¥7800.00
美元价：
4680.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TNF-α-convertingEnzyme;DisintegrinandMetalloproteinaseDomain-containingProtein17;CD156b |
| ProductType | RecombinantAntibody |
| Properties | |
| Clone | D1(A12) |
| Isotype | HumanFabfragment,κ,His-tagged |
| Source/Host | E.coli |
| Immunogen/Antigen | RecombinanthumanADAM17(TACE)ectodomaintaggedtobiotin. |
| Label/Conjugates | PreservativeFree |
| Application | FunctionalApplication(Blocking):InhibitsADAM17activityat15μg/ml(200nM). Optimalconditionsshouldbedeterminedindividually. |
| Crossreactivity | Human |
| Specificity | Recognizesthecatalyticandnon-catalyticdomainofhumanADAM17(TACE)throughitsvariablelight(VL)domainandvariableheavy(VH)domain,respectively.DoesnotbindrecombinantmouseADAM17ectodomain. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | PurifiedbyImmobilizedMetalAffinityChromatography(IMAC). |
| EndotoxinContent | <0.001eu mu;g=""> |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBS. |
| AccessionNumber | UniProtIDP78536 |
| OtherProductData | Thiscross-domainhumanantibodyisaselectiveADAM17(TACE)antagoNISTandprovidesauniquealternativetosmallmoleculemetalloproteaseinhibition.ADAMmultidomaintopologywasexploitedbyfirstisolatinganinhibitoryhumanantibody(D1)thatboundADAM17-specificnon-catalyticregionsexclusivelythroughitsvariableheavy(VH)domain.AD1-VHbiasedscFvphage-displaylibrarywasthenusedtoselectivelyisolateanewvariablelight(VL)chainthatcouldsimultaneouslybindtotheADAM17catalyticdomain.ThismonovalentFabAntibodyhasbeenshownbyC.J.Tape,etal.;PNAS108,5578(2011)tobeasactiveasthedivalentantibody(Prod.No.AG-27B-6000). |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Stableforatleast3monthsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
ADAM17(Disintegrinandmetalloproteinasedomain-containingprotein17),alsocalledTACE(Tumornecrosisfactor-α-convertingenzyme)istheprototypeoftheADAMfamilyofectodomainsheddingproteases(sheddase).ADAM17isunderstoodtobeinvolvedintheprocessingofTNF-αatthesurfaceofthecellandfromwithintheintracellularmembranesofthetrans-Golginetwork.Thisprocessinvolvesthecleavageandreleaseofasolubleectodomainfrommembrane-boundpro-proteins(suchaspro-TNF-α)andisofknownphysiologicalimportance.ADAM17isresponsIBLefortheprocessingofadiversevarietyofmembrane-anchoredcytokines,celladhesionmolecules,receptors,ligandsandenzymes,includingcleavingepidermalgrowthfactorreceptor(EGFR)ligandsandextracellularNotch1.Theproteolyticcleavageisanindispensableactivationeventformanyofthesesubstrates,ADAM17hasemergedasanattractivetherapeutictargetforthetreatmentofinflammatorydiseases(e.g.rheumatoidarthritis)orinflammationassociatedcancer.
ProductReferences
- Cross-domaininhibitionofTACEectodomain:C.J.Tape,etal.;PNAS108,5578(2011)
- Anti-tumoureffectsofaspecificanti-ADAM17antibodyinanovariancancermodelinvivo:F.M.Richards,etal.;PLoSOnee40597(2012)
- iRHOM2isacriticalpathogenicmediatorofinflammatoryarthritis:P.D.Issuree,etal.;J.Clin.Invest.123,928(2013)
- NKcellCD16surfaceexpressionandfunctionisregulatedbyadisintegrinandmetalloprotease-17(ADAM17):R.Romee,etal.;Blood121,3599(2013)
- Developmentofa"mouseandhumancross-reactive"affinity-maturedexositeinhibitoryhumanantibodyspecifictoTACE(ADAM17)forcancerimmunotherapy:H.F.Kwok,etal.;ProteinEng.Des.Sel.27,179(2014)
- TargetingthesheddaseactivityofADAM17byananti-ADAM17antibodyD1(A12)inhibitsheadandnecksquamouscellcarcinomacellproliferationandmotilityviablockageofbradykinininducedHERstransactivation:Y.Huang,etal.;Int.J.Biol.Sci.10,702(2014)
- TargetingADAM-17withaninhibitorymonoclonalantibodyhasantitumoureffectsintriple-negativebreastcancercells:F.Caiazza,etal.;Br.J.Cancer112,1895(2015)
- Recentadvancesinthefieldofanti-cancerimmunotherapy:H.Neves&H.F.Kwok;BBAClinical3,280(2015)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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