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Adipogen/anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)/JAI-MHN-100P/100 µg
![Adipogen/anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)/JAI-MHN-100P/100 µg](https://www.ebiomall.cn/images/adipogen/jai-mhn-ihc-4-hne_stain_2.jpg)
Adipogen/anti-4-Hydroxy-2-nonenal [4-HNE], mAb (HNEJ-2)/JAI-MHN-100P/100 µg
商品编号：
JAI-MHN-100P
品牌：
Adipogen Inc
市场价：
¥13400.00
美元价：
8040.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Product Type | Monoclonal Antibody |
| Properties | |
| Clone | HNEJ-2 |
| Isotype | Mouse IgG1κ |
| Source/Host | Ascites |
| Immunogen/Antigen | 4-Hydroxy-2-nonenal (4-HNE) modified keyhole limpet hemocyanin. |
| Application |
Immunohistochemistry: Recommended concentration is 25μg/mL Western Blot: Recommended concentration is 15μg/mL |
| Crossreactivity |
All Human |
| Specificity | Recognizes 4-HNE-lysine, 4-HNE-histidine and 4-HNE cysteine adduct. Has much higher affinity for the 4-HNE-histidine adduct than 4-HNE-lysine or 4-HNE cysteine adduct. Shows almost negligible reactivity with proteins that were treated with other aldehydes, such as 2-nonenal, 2-hexenal, 1-hexanal, 4-hydroxy-2-hexenal, formaldehyde, or glutaraldehyde. |
| Purity Detail | Ammonium sulfate purified. |
| Formulation | Lyophilized. Contains 50mM Tris-buffered saline (TBS). |
| Reconstitution | Reconstitute with 1000μL of distilled water. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| Declaration | Manufactured by JaICA. |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability |
Stable for at least 3 years after receipt when stored at -20°C. After reconstitution, prepare aliquots and store at -20°C. |
| Documents | |
| Protocols |
 Download PDF |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Reactive oxygen species (ROS) are involved in lipid peroxidation inside the living bodies, and membrane lipids are one of the major targets of ROS. During the peroxidation process, a variery of aldehydes are formed. 4-hydroxy-2-nonenal (4-HNE) is an alpha, beta unsaturated aldehyde that can be formed by peroxidation of omega-6 unsaturated fatty acids such as linoleic acid and arachidonic acid. Especially, 4-HNE formed inside living body is reported to originate from phospholipid-bound arachidonic acid. 4-HNE may be one of the most reliable biomarker of lipid peroxidation.
Product References
- The monclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct: S.Toyokuni, et al.; FEBS Lett. 359, 189 (1995) [Western blot]
- Induction and nuclear translocation of thioredoxin by oxidative damage in the mouse kidney: independence of tubular necrosis and sulfhydryl depletion: T. Tanaka, et al.; Lab. Invest. 77, 145 (1997)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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