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Adipogen/anti-α-Tubulin (acetylated), mAb (TEU318)/AG-20B-0068-C100/100 µg
Adipogen/anti-α-Tubulin (acetylated), mAb (TEU318)/AG-20B-0068-C100/100 µg
商品编号：
AG-20B-0068-C100
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | TEU318 |
| Isotype | MouseIgG1 |
| Source/Host | Purifiedfromconcentratedhybridomatissueculturesupernatant. |
| Immunogen/Antigen | TubulinoftheCiliateEuploteselutedfromthe55kDabandofSDSgel. |
| Application | WesternBlot: 1:2000 ICC:1:2000 |
| Crossreactivity | All |
| Specificity | DetectsK40acetylationofα-tubulin;signalspecificallyincreasedbymodificationwithtubulinacetyltransferaseα-TAT1. |
| Purity | ≥95%(SDS-PAGE) |
| PurityDetail | ProteinG-affinitypurified. |
| Concentration | 1mg/ml |
| Formulation | Liquid.InPBScontaining10%glyceroland0.02%sodiumazide. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afteropening,preparealiquotsandstoreat-20°C. Avoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
MicrotubulesarekeyelementsoftheeukaryoticCytoskeletonthatdynamicallyassemblefromheterodimersofα-andβ-tubulin.Twodifferentmechanismscangeneratemicrotubulediversity:theexpressionofdifferentα-andβ-tubulingenes,referredtoastubulinisotypes,andthegenerationofposttranslationalmodifications(PTMs)onα-andβ-tubulin.TubulinPTMsincludethewell-knownacetylationorphosphorylation,andothersthathavesofarmostlybeenfoundontubulin,detyrosination/tyrosination,polyglutamylationandpolyglycylation.ThesePTMsmighthaveevolvedtospecificallyregulatetubulinandmicrotubulefunctions.TubulinacetylationwasdiscoveredonK40offlagellarα-tubulininChlamydomonasreinhardtiiandisgenerallyenrichedonstablemicrotubulesincells.Itislocatedonthemicrotubulelumenalsurface.Asaresultofitslocalizationattheinnerfaceofmicrotubules,K40acetylationmightratheraffectthebindingofmicrotubuleinnerproteins,apoorlycharacterizedfamilyofproteins.FunctionalexperimentsincellshavefurthersuggestedthatK40acetylationregulatesintracellulartransportbyregulatingthetrafficofkinesinmotorsprobablybyindirectmechanisms.Acetyltransferaseα-Tat1(orMec-17)specificallyacetylateα-tubulinK40.Acetylationoftubulinbyα-Tat1accumulatesselectivelyinstable,long-livedmicrotubulesthusexplainingthelinkbetweenthisposttranslationalmodicationandstablemicrotubulesincells.However,thedirectcellularfunctionofK40acetylationonmicrotubulesisstillunclear.
ProductReferences
- IsolationandcharacterizationoflibrariesofmonoclonalantibodiesdirectedagainstvariousformsoftubulininParamecium:A.M.Callen,etal.;Biol.Cell81,95(1994)
- WhereandwhenismicrotubulediversitygeneratedinParamecium?Immunologicalpropertiesofmicrotubularnetworksintheinterphaseanddividingcells:A.Fleury,etal.;Protoplasma189,37(1995)
- StructuralinheritanceinParamecium:ultrastructuralevidenceforbasalbodyandassociatedrootletspolaritytransmissionthroughbinaryfission:F.Iftode&A.Fleury-Aubusson;Biol.Cell95,39(2003)
- Investigatingtubulinposttranslationalmodificationswithspecificantibodies:M.M.Magiera&C.Janke;InMethodsCellBiol.(Burlington:AcademicPress)115,247(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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