脂肪原/Q-VD-OPh/AG-CP3-0006-M005/5毫克
商品编号：
AG-CP3-0006-M005
品牌：
Adipogen Inc
市场价：
¥11800.00
美元价：
7080.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Q-Val-Asp-OPh;pan-CaspaseInhibitor;N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy)methylketone |
| ProductType | Chemical |
| Properties | |
| Formula | C26H25F2N3O6 |
| MW | 513.5 |
| CAS | 1135695-98-5(anhydrous) |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥95%(TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO. |
| BIOLOGicalActivity | TheIC50rangeforcaspases-1,-3,-8,-9,-10,and-12is25-400nM. |
| OtherProductData | Q-VD-OPhdoesnotexhibittoxiceffectsattypicalworkingconcentrations:10-20μMforinvitrocellcultureapplications,10-120(upto1000)mg/kgforinvivoanimalstudies.Q-VD-OPhisasmallhydrophobiccompoundandrequiresDMSOforsolubilization.Stocksolutionsashighas200mg/mlhavebeenpreparedinDMSO.Toretainsolubilityinwateratconcentrationsabove1mg/ml,80%DMSOissuggested.Fortissueculturestudies10mMor20mMstocksolutionsarepreparedinDMSOanddiluted1:1000directlyintothetissueculturemedium.ForinvivostudiesQ-VD-OPhhasbeenadmiNISTeredin80%to100%DMSOtoassuresolubilityatthedosesgiven. ForNegativeControlseeProd.No.AG-CP3-0007. |
| InChiKey | OOBJCYKITXPCNS-AKRCKQFNSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,irreversIBLeandnon-toxicnon-FMKpan-caspaseinhibitorwithimprovedpotency,stabilityandtoxicityoverZ-VAD-FMK.Doesnotcross-reactwithcathepsinsnorcalpains.Non-toxicduetothe2,6-difluorophenoxymethyl(OPh)group.
- ThepeptideisnotO-methylatedtoreducehydrophobicityandtofacilitateuseinaqueousmedia.
- InhibitsICE-familyprotease/caspaseprocessing,leADIngtoapoptosisandautophagyinduction.
- Decreasesproteasomeactivity.
- Usedinapoptosisandinflammasomestudies.
ProductReferences
- Q-VD-OPh,abroadspectrumcaspaseinhibitorwithpotentantiapoptoticproperties:T.M.Caserta,etal.;Apoptosis8,345(2003)
- SpecificcaspaseinhibitorQ-VD-OPhpreventsneonatalstrokeinP7rat:aroleforgender:S.Renolleau,etal.;J.NeuRochem.100,1062(2007)
- TheroleofcaspasesinAlzheimer"sdisease;potentialnoveltherapeuticopportunities:T.T.Rohn;Apoptosis15,1403(2010)
- Thepan-caspaseinhibitorQ-VD-OPhhasanti-leukemiaeffectsandcaninteractwithvitaminDanalogstoincreaseHPK1signalinginAMLcells:X.Chen-Deutsch,etal.;Leuk.Res.36,884(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
