脂肪原/Q-VD-OPh/AG-CP3-0006-3001/3 x 1毫克
商品编号:
AG-CP3-0006-3001
品牌:
Adipogen Inc
市场价:
¥8400.00
美元价:
5040.00
产品分类:
临床研究
公司分类:
clinical_research
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductDetails | |
---|---|
Synonyms | Q-Val-Asp-OPh;pan-CaspaseInhibitor;N-(2-Quinolyl)-L-valyl-L-aspartyl-(2,6-difluorophenoxy)methylketone |
ProductType | Chemical |
Properties | |
Formula | C26H25F2N3O6 |
MW | 513.5 |
CAS | 1135695-98-5(anhydrous) |
Source/HostChemicals | Synthetic. |
PurityChemicals | ≥95%(TLC) |
Appearance | Whitesolid. |
Solubility | SolubleinDMSO. |
BIOLOGicalActivity | TheIC50rangeforcaspases-1,-3,-8,-9,-10,and-12is25-400nM. |
OtherProductData | Q-VD-OPhdoesnotexhibittoxiceffectsattypicalworkingconcentrations:10-20μMforinvitrocellcultureapplications,10-120(upto1000)mg/kgforinvivoanimalstudies.Q-VD-OPhisasmallhydrophobiccompoundandrequiresDMSOforsolubilization.Stocksolutionsashighas200mg/mlhavebeenpreparedinDMSO.Toretainsolubilityinwateratconcentrationsabove1mg/ml,80%DMSOissuggested.Fortissueculturestudies10mMor20mMstocksolutionsarepreparedinDMSOanddiluted1:1000directlyintothetissueculturemedium.ForinvivostudiesQ-VD-OPhhasbeenadmiNISTeredin80%to100%DMSOtoassuresolubilityatthedosesgiven. ForNegativeControlseeProd.No.AG-CP3-0007. |
InChiKey | OOBJCYKITXPCNS-AKRCKQFNSA-N |
ShippingandHandling | |
Shipping | BLUEICE |
ShortTermStorage | +4°C |
LongTermStorage | -20°C |
HandlingAdvice | Keepcoolanddry. |
Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
Documents | |
MSDS | DownloadPDF |
ProductSpecificationSheet | |
Datasheet | DownloadPDF |
- Cellpermeable,irreversIBLeandnon-toxicnon-FMKpan-caspaseinhibitorwithimprovedpotency,stabilityandtoxicityoverZ-VAD-FMK.Doesnotcross-reactwithcathepsinsnorcalpains.Non-toxicduetothe2,6-difluorophenoxymethyl(OPh)group.
- ThepeptideisnotO-methylatedtoreducehydrophobicityandtofacilitateuseinaqueousmedia.
- InhibitsICE-familyprotease/caspaseprocessing,leADIngtoapoptosisandautophagyinduction.
- Decreasesproteasomeactivity.
- Usedinapoptosisandinflammasomestudies.
ProductReferences
- Q-VD-OPh,abroadspectrumcaspaseinhibitorwithpotentantiapoptoticproperties:T.M.Caserta,etal.;Apoptosis8,345(2003)
- SpecificcaspaseinhibitorQ-VD-OPhpreventsneonatalstrokeinP7rat:aroleforgender:S.Renolleau,etal.;J.NeuRochem.100,1062(2007)
- TheroleofcaspasesinAlzheimer"sdisease;potentialnoveltherapeuticopportunities:T.T.Rohn;Apoptosis15,1403(2010)
- Thepan-caspaseinhibitorQ-VD-OPhhasanti-leukemiaeffectsandcaninteractwithvitaminDanalogstoincreaseHPK1signalinginAMLcells:X.Chen-Deutsch,etal.;Leuk.Res.36,884(2012)
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。
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