![Adipogen/PTACH [NCH 51]/AG-CR1-3667-M005/5 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3667_ptach-nch51.png)
Adipogen/PTACH [NCH 51]/AG-CR1-3667-M005/5 mg
商品编号：
AG-CR1-3667-M005
品牌：
Adipogen Inc
市场价：
¥1400.00
美元价：
840.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Cpd51;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)heptyl)2-methylpropanethioate |
| ProductType | Chemical |
| Properties | |
| Formula | C20H26N2O2S2 |
| MW | 390.56 |
| CAS | 848354-66-5 |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitecrystals. |
| Solubility | SolubleinDMSO(25mg/ml)orethanol(10mg/ml).Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | MDYDGUOQFUQOGE-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentnon-hydroxamateHDACinhibitor(HDACi)(IC50:32,48and41nMforHDAC4,HDAC1andHDAC6,respectively).
- CellpermeableprodrugthatisintracellularlyconvertedtothepotentHDACinhibitorNCH31.
- PredictedtoexhibitasimilarHDACbindingmodeasthatofSAHA,interactingwiththeactive-sitezinctargetinggroup.
- ShowntoexhibitcomparableantiproliferativeandapoptoticactivityasSAHAagainstvariouscancercelllines.Inhibitsgrowthofvariouscancercellsinvitro(EC50=1.1-9.1μM).
- ReactivateslatentHIV-1geneexpression.
- Activeagainstselectedneurodevelopmentaldisorders.
ProductReferences
- Novelinhibitorsofhumanhistonedeacetylases:design,synthesis,enzymeinhibition,andcancercellgrowthinhibitionofSAHA-basednon-hydroxamates:T.Suzuki,etal.;J.Med.Chem.48,1019(2005)
- ProteomeanalysesofthegrowthinhibitoryeffectsofNCH-51,anovelhistonedeacetylaseinhibitor,onlymphoidmalignantcells:T.Sanda,etal.;Leukemia21,2344(2007)
- Identificationofapotentandstableantiproliferativeagentbytheprodrugformationofathiolatehistonedeacetylaseinhibitor:T.Suzuki,etal.;Bioorg.Med.Chem.Lett.17,1558(2007)
- NovelhistonedeacetylaseinhibitorNCH-51activateslatentHIV-1geneexpression:A.F.Victoriano,etal.;FEBSLett.585,1103(2011)
- ImmunologicalandpharmacologicalstrategiestoreactivateHIV-1fromlatentlyinfectedcells:apossibilityforHIV-1paediatricpatients?M.Martinez-Bonet,etal.;J.VirusErad.1,148(2015)
- AlteredneuronalnetworkandrescueinahumanMECP2duplicationmodel:S.Nageshappa,etal.;Mol.Psychiatry21,178(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
