脂肪原/CYLD亚型1（人类）（记录）（His）/AG-40T-0231-C050/50µg
商品编号：
AG-40T-0231-C050
品牌：
Adipogen Inc
市场价：
¥8940.00
美元价：
5364.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UbiquitinC-terminalHydrolaseCYLD;DeubiquitinatingEnzymeCYLD;UbiquitinThioesteraseCYLD;Ubiquitin-specific-processingProteaseCYLD;CYLD1 |
| ProductType | Protein |
| Properties | |
| Source/Host | Sf21cells |
| Sequence | HumanCYLDIsoform1(AccessionNr.Q9NQC7-1)fusedtoaN-terminalHis-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.InHEPES,NaClandDTT. |
| OtherProductData | Use:Ubiquitin-specificdeconjugatingenzyme.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof50-500nM. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitincarboxyl-terminalhydrolaseCYLDisa956aminoacid(aa)memberofthepeptidaseC67proteinfamilywithapredictedmolecularweightof107kDa.ThemouseandratCYLDorthologsshare95%and94%aasequenceidentitywiththehumanprotein,respectively.TwoisoformsofCYLDhavebeenidentified,afull-lengthisoformandasecondisoformthatlacksaa305-307duetoalternativesplicing.ExpressionofCYLDhasbeenreportedinfetalbrainaswellasadultbrain,heart,leukocytes,skeletalmuscle,spleenandtestis.CYLDactsasadeubiquitinaseandremovesK63-linkedubiquitinchainsfrommultiplesubstratesincludingIκB,c-Jun,andc-Fos,resultingintheinhibitionofNF-κBandJNKsignaling.Insomecontexts,CYLDenhancesmitosisentryandithasalsobeenshowntodelayG1/SphaseentrysuggestingthatCYLDregulatesmultiplephasesofthecellcycle.CYLDisrecognizedasatumorsuppressorandmutationsinCYLDresultinskinappendagesyndromesincludingBrooke-SpiegleSyndrome,familialcylindromatosisandfamilialtrichoepitheliomastype1.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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