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Adipogen/CD28 (human):Fc (human) (rec.)/CHI-HF-210CD28-C200/200 µg
Adipogen/CD28 (human):Fc (human) (rec.)/CHI-HF-210CD28-C200/200 µg
商品编号：
CHI-HF-210CD28-C200
品牌：
Adipogen Inc
市场价：
¥7200.00
美元价：
4320.00
产品分类：
临床研究
公司分类：
clinical_research
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Protein |
| Properties | |
| Source/Host | CHOcells |
| Sequence | TheextracellulardomainofhumanCD28(aa19-152)isfusedtotheN-terminusoftheFcregionofhumanIgG1. |
| Crossreactivity | Human |
| BIOLOGicalActivity | MeasuredbyitsbindingABIlityinafunctionalELISA.ImmobilizedCD28(human):Fc(human)(rec.)(#CHI-HF-210CD28)at20μg/ml(50μl/well)canbindtheproteinCD80(human):Fc(mouse)(rec.)(#CHI-HF-211CD80).TheEC50isabout0.05μg/ml. |
| Purity | ≥98%(SDS-PAGE) |
| EndotoxinContent | <0.06eu mu;g="" protein="" (lal="" test;="" lonza).=""> |
| Reconstitution | Reconstituteat100μg/mlinsterilePBS. |
| Formulation | Lyophilizedfrom0.2μm-filteredsolutioninPBS. |
| OtherProductData | NCBIreferenceAAA60581.1:CD28(human) |
| Declaration | ManufacturedbyChimerigen. |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Avoidfreeze/thawcycles. |
| Use/Stability | Stableforatleast1yearafterreceiptwhenstoredat-20°C. Workingaliquotsarestableforupto3monthswhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CD28andCTLA-4togetherwiththeirligands,CD80(B7-1)andCD86(B7-2),constituteoneofthedominantcostimulatorypathwaysthatregulateTandBcellresponses.CD28andCTLA-4arestructurallyhomologousmoleculesthataremembersoftheimmunoglobulin(Ig)genesuperfamily.BothCD28andCTLA-4arecomposedofasingleIgV-likeextracellulardomain,atransmembranedomainandanintracellulardomain.CD28andCTLA-4arebothexpressedonthecellsurfaceasdisulfide-linkedhomodimersorasmonomers.Thegenesencodingthesetwomoleculesarecloselylinkedonhumanchromosome2andmousechromosome1.MouseCD28isexpressedconstitutivelyonvirtually100%ofmouseTcellsandondevelopingthymocytes.CellsurfaceexpressionofmouseCD28isdownregulateduponligationofCD28inthepresenceofPMAorPHA.Incontrast,CTLA-4isnotexpressedconstitutivelybutisupregulatedrapidlyfollowingTcellactivationandCD28ligation.CellsurfaceexpressionofmouseCTLA-4peaksapprox.y48hoursafteractivation.AlthoughbothCTLA-4andCD28canbindtothesameligands,CTLA-4bindstoB7-1andB7-2witha20-100foldhigheraffinitythanCD28.CD28/B7interactionhasbeenshowntopreventapoptosisofactivatedTcellsviatheupregulationofbcl-XL.CD28ligationhasalsobeenshowntoregulateTh1/Th2differentiation.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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