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Adipogen/Ubiquitin vinyl sulfone (human) (rec.) (HA)/AG-40T-0517-C025/25 µg
Adipogen/Ubiquitin vinyl sulfone (human) (rec.) (HA)/AG-40T-0517-C025/25 µg
商品编号：
AG-40T-0517-C025
品牌：
Adipogen Inc
市场价：
¥7640.00
美元价：
4584.00
产品分类：
其它重组蛋白
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Ub-VS |
| ProductType | Protein |
| Properties | |
| Source/Host | E.coli |
| Sequence | Humanubiquitin(AccessionNr.P0CG47)taggedtovinylsulfonefusedtoaN-terminalHA-tag. |
| Crossreactivity | Human |
| Formulation | Liquid.In50mMMES,pH6.0. |
| OtherProductData | Use:Potent,irreversIBLeandspecificinhibitorofmostdeubiquitinatingenzymes(DUBs)includingubiquitinC-terminalhydrolases(UCHs)andubiquitin-specificproteases(USPs).Usefulforinhibitingthehydrolysisofpoly-ubiquitinchainsonsubstrateproteinsinvitroandthusenhancespoly-ubiquitinchainaccumulation.TheHA-tagallowsfordetectionandpurificationofdeubiquitinatingenzymesactivity.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof1-5µMforinvitroassaystoinhibitdeubiquitinatingenzymes. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Ubiquitinisa76aminoacid(aa)proteinthatisubiquitouslyexpressedinalleukaryoticorganisms.ubiquitinishighlyconservedwith96%aasequenceidentitysharedbetweenhumanandyeastubiquitin,and100%aasequenceidentitysharedbetweenhumanandmouseubiquitin.Inmammals,fourubiquitingenesencodefortwoubiquitin-ribosomalfusionproteinsandtwopoly-ubiquitinproteins.Cleavageoftheubiquitinprecursorsbydeubiquitinatingenzymesgivesrisetoidenticalubiquitinmonomerseachwithapredictedmolecularweightof8.6kDa.ConjugationofubiquitintotargetproteinsinvolvestheformationofanisopeptidebondbetweentheC-terminalglycineresidueofubiquitinandalysineresidueinthetargetprotein.Thisprocessofconjugation,referredtoasubiquitinationorubiquitylation,isamulti-stepprocessthatrequiresthreeenzymes:aubiquitin-activating(E1)enzyme,aubiquitin-conjugating(E2)enzyme,andaubiquitinligase(E3).ubiquitinationisclassicallyrecognizedasamechanismtotargetproteinsfordegradationandasaresult,ubiquitinwasoriginallynamedATP-dependentProteolysisFactor1(APF-1).Inadditiontoproteindegradation,ubiquitinationhasbeenshowntomediateavarietyofBIOLOGicalprocessessuchassignaltransduction,endocytosis,andpost-endocyticsorting.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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