脂肪原/泛素(V70A突变体)(人类)(rec.)/AG-40T-0509-M001/1 mg
商品编号:
AG-40T-0509-M001
品牌:
Adipogen Inc
市场价:
¥2760.00
美元价:
1656.00
产品分类:
其它重组蛋白
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductDetails | |
---|---|
Synonyms | UBB;UbiquitinB |
ProductType | Protein |
Properties | |
Source/Host | E.coli |
Sequence | HumanubiquitinV70Amutant(AccessionNr.P0CG47). |
Crossreactivity | Human |
Formulation | Lyophilizedfromasolutionindeionizedwater. |
OtherProductData | Use:Canformaubiquitin-activating(E1)enzyme-catalyzedactivethioesterattheC-terminusallowingthemoleculetobetransferredtothelysinesofsubstrateproteins.Canbeconjugatedtosubstrateproteinsviathesubsequentactionsofaubiquitin-activating(E1)enzyme,aubiquitin-conjugating(E2)enzyme,andaubiquitinligase(E3).ChainsconsistingofmutantV70Aareunabletointeractwithandbedegradedbythe26SProteasome.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.2-1mM. |
Declaration | ManufacturedbyBostonBiochem |
ShippingandHandling | |
Shipping | BLUEICE |
ShortTermStorage | +4°C |
LongTermStorage | -20°C |
HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
Documents | |
MSDS | No |
ProductSpecificationSheet | |
Datasheet | DownloadPDF |
Ubiquitinisa76aminoacid(aa)proteinthatisubiquitouslyexpressedinalleukaryoticorganisms.ubiquitinishighlyconservedwith96%aasequenceidentitysharedbetweenhumanandyeastubiquitin,and100%aasequenceidentitysharedbetweenhumanandmouseubiquitin.Inmammals,fourubiquitingenesencodefortwoubiquitin-ribosomalfusionproteinsandtwopoly-ubiquitinproteins.Cleavageoftheubiquitinprecursorsbydeubiquitinatingenzymesgivesrisetoidenticalubiquitinmonomerseachwithapredictedmolecularweightof8.6kDa.ConjugationofubiquitintotargetproteinsinvolvestheformationofanisopeptidebondbetweentheC-terminalglycineresidueofubiquitinandalysineresidueinthetargetprotein.Thisprocessofconjugation,referredtoasubiquitinationorubiquitylation,isamulti-stepprocessthatrequiresthreeenzymes:aubiquitin-activating(E1)enzyme,aubiquitin-conjugating(E2)enzyme,andaubiquitinligase(E3).ubiquitinationisclassicallyrecognizedasamechanismtotargetproteinsfordegradationandasaresult,ubiquitinwasoriginallynamedATP-dependentProteolysisFactor1(APF-1).Inadditiontoproteindegradation,ubiquitinationhasbeenshowntomediateavarietyofBIOLOGicalprocessessuchassignaltransduction,endocytosis,andpost-endocyticsorting.UbiquitinhasadistinctandfunctionallyimportanthydrophobicpatchwhosesurfaceisdefinedbythreeresiduesincludingLeu8,Ile44andVal70.TheseresiduesaresolventaccessIBLeinubiquitinchainsandarecriticalforpoly-ubiquitinchaininteractionandrecognitionbythe26SProteasomeandsubsequenttargetdegradation.Thesehydrophobicresiduesinteractdirectlywithvariousfactorsthatbindtoubiquitinand/ormediateubiquitin-ubiquitininteractionsinubiquitinchainsthatmayinfluenceorientationandrecognition.
品牌介绍
Adipogen公司由三个子公司组成,分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国,运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发,如癌症、免疫、炎症、代谢疾病(糖尿病、肥胖)、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外,也可提供抗体和蛋白产品,Adipogen拥有自己的化学实验室,致力于开发创新型小分子化合物。
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