脂肪原/吡咯烷酮A/AG-CN2-0106-C250/250µg
商品编号：
AG-CN2-0106-C250
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (+)-PyripyropeneA;PPPA;FO1289A |
| ProductType | Chemical |
| Properties | |
| Formula | C31H37NO10 |
| MW | 583.6 |
| CAS | 147444-03-9 |
| Source/HostChemicals | IsolatedfromAspergillusfumigatusFO-1289. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Palepinktorustybrownsolid. |
| Solubility | Solubleinmethanol,chloroform,ethylacetateorDMSO.Insolubleinwaterorhexane. |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| InChiKey | PMMQOFWSZRQWEV-RVTXXDJVSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Highlyspecificinhibitorofacyl-coenzymeA:cholesterolacetyltransferase2(ACAT2)[1-6,8,9].
- Anti-angiogenic[10].
- Antiatherogenicandantiatheroscleroticagent.Showscholesterol-loweringandatheroprotectiveactivities.[7,11,12].
ProductReferences
- Pyripyropenes,highlypotentinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus:S.Omura,etal.;J.Antibiot.(Tokyo)46,1168(1993)
- Pyripyropenes,novelinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus.II.StructureelucidationofpyripyropenesA,B,CandD:Y.K.Kim,etal.;J.Antibiot.(Tokyo)47,154(1994)
- Pyripyropenes,novelinhibitorsofacyl-CoA:cholesterolacyltransferaseproducedbyAspergillusfumigatus.I.Production,isolation,andBIOLOGicalproperties:H.Tomoda,etal.;J.Antibiot.(Tokyo)47,148(1994)
- Mass-productionofhumanACAT-1andACAT-2toscreenisoform-specificinhibitor:adifferentsubstratespecificityandinhibitoryregulation:K.H.Cho,etal.;BBRC309,864(2003)
- IdentificationofACAT1-andACAT2-specificinhibitorsusinganovel,cell-basedfluorescenceassay:individualACATuniqueness:A.T.Lada,etal.;J.LipidRes.45,378(2004)
- Selectivityofmicrobialacyl-CoA:cholesterolacyltransferaseinhibitorstowardisozymes:T.Ohshiro,etal.;J.Antibiot.(Tokyo)60,43(2007)
- Potentialtherapeuticsforobesityandatherosclerosis:inhibitorsofneutrallipidmetabolismfrommicroorganisms:H.Tomoda&S.Omura;Pharmacol.Ther.115,375(2007)(Review)
- Identificationoftheinteractionsitewithinacyl-CoA:cholesterolacyltransferase2fortheisoform-specificinhibitorpyripyropeneA:A.Das,etal.;J.Biol.Chem.283,10453(2008)
- Selectivityofpyripyropenederivativesininhibitiontowardacyl-CoA:cholesterolacyltransferase2isozyme:T.Ohshiro,etal.;J.Antibiot.(Tokyo).61,503(2008)
- Pyripyropenes,fungalsesquiterpenesconjugatedwithalpha-pyroneandpyridinemoieties,exhibitsanti-angiogenicactivityagainsthumanumbilicalveinendothelialcells:A.Hayashi,etal.;Biol.Pharm.Bull.32,1261(2009)
- PyripyropeneA,anacyl-coenzymeA:cholesterolacyltransferase2-selectiveinhibitor,attenuateshypercholesterolemiaandatherosclerosisinmurinemodelsofhyperlipidemia:T.Ohshiro,etal.;Arterioscler.Thromb.Vasc.Biol.31,1108(2011)
- Isoform-specificinhibitorsofACATs:recentadvancesandpromisingdevelopments:T.Ohshiro&H.Tomoda;FutureMed.Chem.3,2039(2011)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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