脂肪原/嘌呤霉素。盐酸/AG-CN2-0078-M025/25 mg
商品编号：
AG-CN2-0078-M025
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CL16,536;NSC3055;Stylomycin |
| ProductType | Chemical |
| Properties | |
| Formula | C22H29N7O5.2HCl |
| MW | 471.5.72.9 |
| MerckIndex | 14:7943 |
| CAS | 58-58-2 |
| RTECS | AU7355000 |
| Source/HostChemicals | IsolatedfromStreptomycesalboniger. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | Solubleinwater. |
| OtherProductData | NOTE:Theworkingpuromycinconcentrationforselectioninmammaliancelllinesrangesfrom1-10µg/ml.Priortousingthepuromycinantibiotic,titratetheselectionagenttodeterminetheoptimalconcentrationfortargetcellline.Usethelowestconcentrationthatkills100%ofnon-transfectedcellsin3-5daysfromthestartofpuromycinselection.Seealsoonlineselection-protocol. |
| InChiKey | RXWNCPJZOCPEPQ-NIAQAADTBJ |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| Protocols |  DownloadPDF |
| MSDS | DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Aminonucleosideantibiotic.
- Proteinsynthesisinhibitor.Disruptspeptidetransferonribosomes(actingasanacyl-tRNAanalog)causingprematurechainterminationduringtranslation.Translationalinhibitorinprokaryoticandeukaryoticcellsinbothinvitroandinvivosystems.
- Inhibitsthetransportofproteinsintothemitochondriainvitro.
- ReversIBLeinhibitorofdipeptidyl-peptidaseII(serinepeptidase)andcytosolalanylaminopeptidase(metallopeptidase).
- Apoptosisinducer.
- InhibitsthegrowthofGram-positivebacteria,variousanimalandinsectcells.FungiandGram-negativebacteriaareresistantduetothelowpermeabilitytotheantibiotic.
- Antineoplasticagent.
- UsedincellBIOLOGyasselectiveagentincellculturesystems.ItallowsselectionforcellsthatcontaintheresistancegenepuromycinN-acetyl-transferase(PAC).Puromycinhasafastmodeofaction,causingrapidcelldeathatlowantibioticconcentrations.Adherentmammaliancellsaresensitivetoconcentrationsof2to5µg/ml,whilecellsinsUSPensionaresensitivetoconcentrationsaslowas0.5to2µg/ml.Puromycin-resistantstablemammaliancelllinescanbegeneratedinlessthanoneweek.
ProductReferences
- Puromycininhibitionofproteinsynthesis:M.A.Darken;Pharmacol.Rev.16,223(1964)(Review)
- Mechanismofpuromycinaction:fateofribosomesafterreleaseofnascentpolypeptidechainsfrompolysomes:M.E.Azzam&D.Algranati;PNAS70,3866(1973)
- Inhibitionofaminopeptidaseandacetylcholinesterasebypuromycinandpuromycinanalogs:L.B.Hersh;J.NeuRochem.36,1594(1981)
- Isolationandpropertiesofapuromycinacetyltransferasefrompuromycin-producingStreptomycesalboniger:S.Y.Paik,etal.;J.Antibiot.(Tokyo)38,1761(1985)
- BiosynthesisofpuromycinbyStreptomycesalboniger.CharacterizationofpuromycinN-acetyltransferase:J.Vara,etal.;Biochemistry24,8074(1985)
- Molecularanalysisofthepacgeneencodingapuromycin-N-acetyltransferasefromStreptomycesalboniger:R.A.Lacalle,etal.;Gene79,375(1989)
- UseofpuromycinN-acetyltransferase(PAC)asanewreportergeneintransgenicanimals:E.GomezLahoz,etal.;NucleicAcidsRes.19,3465(1991)
- PacgeneasefficientdominantMarkerandreportergeneinmammaliancells:S.DeLaLuna&J.Ortin;Meth.Enzymol.216,376(1992)
- PuromycinreactionfortheAsite-boundpeptidyl-tRNA:Y.Semenkov,etal.;FEBSLett.296,207(1992)
- UnexpectedcytokineticeffectsinducedbypuromycinincludeaG2-arrest,ametaphase-mitotic-arrest,andapoptosis:A.N.Davidoff&B.V.Mendelow;Leuk.Res.16,1077(1992)
- PuromycinisapotentandspecificinhibitoroftyrosinekinaseactivityinHL-60cells:A.N.Davidoff&B.V.Mendelow;AnticancerRes.12,1761(1992)
- PuromycininhibitsproteinimportintomitochondriabyinterferingwithanintramitochondrialATP-dependentreaction:J.Price&K.Verner;Biochim.Biophys.Acta1150,89(1993)
- Puromycin-sensitiveaminopeptidase.Sequenceanalysis,expression,andfunctionalcharacterization:D.B.Constam,etal.;J.Biol.Chem.270,26931(1995)
- AsimpleassayforpuromycinN-acetyltransferase:selectablemarkerandreporter:C.Mielke,etal.;TrendsGenet.11,258(1995)
- Cellproliferationandapoptosisoftheglomerularepithelialcellsinratswithpuromycinaminonucleosidenephrosis:H.Shiiki,etal.;Pathobiology66,221(1998)
- PuromycinAminonucleosideInducesGlomerularEpithelialCellApoptosis:V.Sanwal,etal.;Exp.Mol.Pathol.70,54(2001)
- IncreasedApoptosisinAcutePuromycinAminonucleosideNephrosis:L.Fernandez,etal.;Exp.Nephrol.9,99(2001)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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