Adipogen/Prostaglandin E<sub>2</sub>/AG-CL1-0001-M001/1 mg
商品编号：
AG-CL1-0001-M001
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PGE2;Dinoprostone;9-Oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oicacid;ProstinE2;Prepidil;NSC165560;11α,15α-Dihydroxy-9-oxo-5-cis,13-trans-prostADIenoicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C20H32O5 |
| MW | 352.5 |
| MerckIndex | 14:7877 |
| CAS | 363-24-6 |
| RTECS | UK8000000 |
| Source/HostChemicals | Synthetic(originallyisolatedfromsheepprostate). |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | Solubleinethanol(50mg/ml),DMSO(50mg/ml)orDMF(100mg/ml).SparinglysolubleinPBS,pH7.2(5mg/ml). |
| Crossreactivity | Multi-species |
| OtherProductData | DonotaddPGE2tobasicsolutionwithpH>7.4. |
| InChiKey | XEYBRNLFEZDVAW-ARSRFYASSA-N |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Oneofthemosttypicallipidmediatorsproducedfromarachidonicacid(AA)bycyclooxygenase(COX)astherate-limitingenzymeandactsonfourkindsofreceptorsubtypes(EP1,EP2,EP3andEP4)withhighbindingaffinity(Kdvaluesrangebetween~1-10nM).
- Regulatorofnumerousphysiologicalfunctionsrangingfromreproductiontoneuronal,metabolicandimmunefunctions.
- Impliedintheregulationofbodytemperatureandsleep-wakeactivity.Regulatingfactorforboneformationandbonehealing.Potentvasodilator.Influencessmoothmusclerelaxation,fertilityandgastricmucosalintegrity(firstlineofdefenseoftheintestinalimmunesystem).
- Actsasapro-inflammatorymediator,butalsoexertsanti-inflammatoryresponses.Aspro-inflammatorymediator,PGE2contributestotheregulationofthecytokineexpressionprofileofDCsandhasbeenreportedtobiasTcelldifferentiationtowardsaThelper(Th)1orTh2response.Exertsanti-inflammatoryactionsoninnateimmunecellslikeneutrophils,monocytesandNKcells.
- ImplicatedinvarioustumOrigenicprocesses.FacilitatestumorprogressionthroughstimulationofangiogenesisviaEP2,mediatescellinvasionandmetastasisformationviaEP4andpromotescellsurvivalbyinhibitingapoptosisvianumeroussignalingpathways.Tumorcell-producedPGE2hasbeenimplicatedinstrategiesoftumorsforevasionofimmunesurveillance.FurThermore,itcanenhancetheinhibitoryfunctionofhumanregulatoryTcells.
- Regulatesvertebratehematopoieticstemcell(HSC)homeostasis.
- InhibitsNLRP3byactingthroughreceptorEP4activationthatincreasescAMP.cAMPactivatesPKAthatphosphorylatesNLRP3atserine295.PKAphosphorylationofNLRP3inhibitstheNLRP3ATPaseactivity,whichisrequiredforassemblyofNLRP3-ASCcomplexes.
ProductReferences
- ProstaglandinE2atnewglance:novelinsightsinfunctionaldiversityoffertherapeuticchances:D.F.Legler,etal.;Int.J.Biochem.CellBiol.42,198(2010)(Review)
- ProstaglandinE2,animmunoactivator:D.Sakata,etal.;J.Pharmacol.Sci.112,1(2010)(Review)
- NewlyemergingrolesforprostaglandinE2regulationofhematopoiesisandhematopoieticstemcellengraftment:E.M.Durand,etal.;Curr.Opin.Hematol.17,308(2010)(Review)
- Prostanoidsignaling:dualroleforprostaglandinE2inneurotoxicity:D.Milatovic,etal.;Neurotoxicol.32,312(2011)(Review)
- ProstaglandinE2EPreceptorsastherapeutictargetsinbreastcancer:J.Reader,etal.;CancerMetastasisRev.30,449(2011)(Review)
- ProstaglandinE2andTcells:friendsorfoes?V.Sreeramkumar,etal.;Immunol.CellBiol.90,579(2012)(Review)
- RegulationofimmuneresponsesbyprostaglandinE2:P.Kalinski;J.Immunol.188,21(2012)(Review)
- PolarizationoftheinnateimmuneresponsebyprostaglandinE2:apuzzleofreceptorsandsignals:M.Rodriguez,etal.;Mol.Pharmacol.85,187(2014)(Review)
- ProstaglandinE2-inducedinflammation:RelevanceofprostaglandinEreceptors:K.Kawahara,etal.;Biochim.BiophysActa.1851,414(2015)(Review)
- ProstaglandinE2andtheEPreceptorsinmalignancy:possIBLetherapeutictargets?G.O"Callaghan&A.Houston;Br.J.Pharmacol.172,5239(2015)(Review)
- ProstaglandinE2InhibitsNLRP3InflammasomeActivationthroughEP4ReceptorandIntracellularCyclicAMPinHumanMacrophages:M.Sokolowska,etal.;J.Immunol.194,5472(2015)
- NLRP3inflammasomeinhibitionisdisruptedinagroupofauto-inflammatorydiseaseCAPSmutations:L.Mortimer,etal.;Nat.Immunol.(Epubaheadofprint)(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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