Adipogen/Ganglioside GM1 . sodium salt/AG-CN2-9000-M005/5 mg
商品编号：
AG-CN2-9000-M005
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | GM1.Na;MonosialogangliosideGM1.Na |
| ProductType | Chemical |
| Properties | |
| Formula | C73H130N3O31.Na |
| MW | 1545.8.23.0(calculatedonsphingosine C18:1andstearicacid) |
| Sequence | Structure:II3Neu5AcGgOse4Cer;β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer;Cer:SphingosineC18:1-C20:1,~1:1byvol.;stearicacidover90% |
| MerckIndex | 14:4364 |
| CAS | 37758-47-7 |
| Source/HostChemicals | Isolatedfrombovinebrain. |
| PurityChemicals | ≥98%(TLC) |
| Solubility | Solubleinwater(micellaraggregates)orchloroform:methanol(2:1). |
| Formulation | Lyophilized. |
| EndotoxinContent | Notdetectable. |
| Identity | Determinedby1H-NMR,MSandHPTLC. |
| InChiKey | LFNNYGUBFYVSKX-FPEJYKFLSA-M |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Hygroscopic. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Gangliosidesareacidicglycosphingolipidsthatformlipidraftsintheouterleafletofthecellplasmamembrane,especiallyinneuronalcellsinthecentralnervoussystem.Theyparticipateincellularproliferation,differentiation,adhesion,signaltransduction,cell-to-cellinteractions,tumOrigenesisandmetastasis.Theaccumulationofgangliosideshasbeenlinkedtoseveraldiseases.GangliosideGM1isamajorsialoglycolipidofneuronalmembranesthatmodulatescalciumhomeostasisandwhichisimportantforneuronalplasticityandrepairmechanisms.ItbindstocholeratoxinBsubunit,resultinginstimulationofadenylylcyclaseinawidevarietyofcelltypes.AftercholeratoxinbindstomembraneassociatedMonosialogangliosideGM1,theAsubunitofcholeratoxinistranslocatedtothecellinterior,whereitcatalyzestheADPribosylationofthemembraneassociatedGssubunitofadenylylcyclase.Inaddition,bindingofcholeratoxintomonosialogangliosideGM1causestranslocationofNF-κBandactivationofdendriticcells.E.coliheat-labileenterotoxin(LT)isstructurallyandfunctionallysimilartocholeratoxinandbindsGM1aswell.GM1hasalsobeenshowntoimproveParkinson"sdiseasesymptomsandslowit"sprogression.
ProductReferences
- Roleofmembranegangliosidesinthebindingandactionofbacterialtoxins:P.H.Fishman;J.Membr.Biol.69,85(1982)
- Promotionofneuritogenesisinmouseneuroblastomacellsbyexogenousgangliosides.RelationshipbetweentheeffectsandthecellsassociationofgangliosideGM1:L.Facci,etal.;J.NeuRochem.42,299(1984)
- AbacteriumlipopolysaccharidethatelicitsGuillain-BarrésyndromehasaGM1ganglioside-likestructure:N.Yuki,etal.;J.Exp.Med.178,1771(1993)
- GangliosideGM1bindstotheTrkproteinandregulatesreceptorfunction:T.Mutoh,etal.;PNAS92,5087(1995)
- Dynamicandstructuralpropertiesofsphingolipidsasdrivingforcetotheformationofmembranedomains:S.Sonnino,etal.;Chem.Rev.106,2111(2006)
- GM1gangliosideinParkinson"sdisease:Resultsofafiveyearopenstudy:J.S.Schneider,etal.;J.Neurol.Sci.292,45(2010)
- Heat-LabileEnterotoxin:BeyondGM1Binding:B.Mudrak&M.J.Kuehn;Toxins2,1445(2010)
- Newfindingsonnucleargangliosides:overviewonmetabolismandfunction:R.Ledeen&G.Wu;J.Neurochem.116,714(2011)
- BindingofCFA/IpiliofenterotoxigenicEscherichiacolitoAsialo-GM1ismediatedbytheminorpilinCfaE:T.P.Madhavan,etal.;Infect.Immun.84,1642(2016)
- PhenotypicAnalysisRevealsthatthe2010HaitiCholeraEpidemicIsLinkedtoaHypervirulentStrain:K.J.F.Satchell,etal.;Infect.Immun.84,2473(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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