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Adipogen/SUMO1 (human) (rec.) Mutant Protein Set/AG-44T-0137-KI01/1 Set
Adipogen/SUMO1 (human) (rec.) Mutant Protein Set/AG-44T-0137-KI01/1 Set
商品编号：
AG-44T-0137-KI01
品牌：
Adipogen Inc
市场价：
¥12320.00
美元价：
7392.00
产品分类：
其它检测试剂盒
公司分类：
Other_kits
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SmallUbiquitin-relatedModifier1;GAP-modifyingProtein1;SMT3C,SMT3H3,UBL1;Sentrin;Ubiquitin-homologyDomainProteinPIC1 |
| ProductType | Set |
| Properties | |
| ApplicationSet | CompoundScreening |
| Crossreactivity | Human |
| KitContains | 50μgofSUMO1wildtype 50μgofSUMO1K7R 50μgofSUMO1K16R 50μgofSUMO1K17R 50μgofSUMO1K7RK16R 50μgofSUMO1K7RK17R 50μgofSUMO1K16RK17R 50μgofSUMO1K7RK16RK17R |
| OtherProductData | Use:Theproteinsinthiskithavetheselysineresiduesmutatedtoarginineandcanbeusedtoinvestigatemono-SUMOylationrequirementsortoreducepoly-SUMOchainformation.Includediswild-typeSUMO-1tobeusedasapositivecontrolinSUMO-1conjugationassayswhichcanbeperformedusingtheSUMO-1ConjugationKit.Typicalconcentrationtosupportconjugationreactioninvitrois10µM-50µMdependingonconditions. |
| Declaration | ManufacturedbyBostonBiochem |
| ShippingandHandling | |
| Shipping | DRYICE |
| ShortTermStorage | -20°C |
| LongTermStorage | -80°C |
| HandlingAdvice | Aliquottoavoidfreeze/thawcycles. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-80°C. |
| Documents | |
| Manual |  DownloadPDF |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Theubiquitin-likeSUMO-1isconjugatedtoavarietyofproteinsinthepresenceofUbc9andtheSUMOE1activatingenzyme(SAE1/SAE2inhuman,orAos1/Uba2pinyeast).TheheterodimericSAE1/SAE2complex(38and70kDarespectively)usesATPtoadenylatetheC-terminalglycineresidueofSUMO-1,formingahigh-energythiolesterbondwiththeSAE2subunit.Thesecondstepisthetrans-esterificationreactionwherebytheactivatedSUMO-1istransferredtoCys93ofUbc9.Ubc9isamemberoftheE2familyandishomologoustoubiquitinconjugatingenzymes,butisspecificfortheconjugationofSUMOtoavarietyoftargetproteins.ThisE2isunusualinthatitinteractsdirectlywithproteinsubstratesthataremodifiedbysumolyationandmayplayaroleinsubstraterecognition.Sumoylatedsubstratesareprimarilylocalizedtothenucleus(RanGAP-1,RANBP2,PML,p53,Sp100,HIPK2)buttherearealsocytosolicsubstrates(IκBα,GLUT1,GLUT4).SUMOmodificationhasbeenimplicatedinfunctionssuchasnucleartransport,chromosomesegregationandtranscriptionalregulation,apoptosis,proteinfunctionandstability.
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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