Adipogen/anti-CREB5, mAb (7D4)/YIF-LF-MA0221/100 µl
商品编号：
YIF-LF-MA0221
品牌：
Adipogen Inc
市场价：
¥6160.00
美元价：
3696.00
产品分类：
功能性抗体
公司分类：
Functional_antibody
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | CREB5;CREBPA;CREB-5;CRE-BPa;cAMP-responsiveElement-bindingProtein5;CyclicAMP-responsiveElement-bindingProtein5 |
| ProductType | MonoclonalAntibody |
| Properties | |
| Clone | 7D4 |
| Isotype | MouseIgG1κ |
| Immunogen/Antigen | RecombinanthumanHis-CREB5proteinpurifiedfromE.coli. |
| Application | ELISA WesternBlot(1:2,000) |
| Crossreactivity | Human Mouse Rat |
| PurityDetail | Ammoniumsulfateprecipitation. |
| Formulation | Liquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| Declaration | ManufacturedbyAbFrontier |
| ShippingandHandling | |
| Shipping | BLUEICE |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
CREB(cAMPresponseelement-binding)proteinsaretranscriptionfactorswhichbindtocertainsequencescalledcAMPresponseelements(CRE)inDNA.Transcriptionfactorsplayakeyroleincontrollingcellproliferation,cellcycleprogression,fuelmetabolismandsoonthroughchangesintargetgenetranscription.CREBhasmanyfunctionsinmanydifferentorgansalthoughmostofitsfunctionshavebeenstudiedinrelationtothebrain.CREBproteinsinneuronsarethoughttobeinvolvedintheformationoflong-termmemories.CRE-BP1isoneofthemostabundantCRE-bindingproteins.ThelevelofitsmRNAisfairlyabundantinsomeregionsofthebrainsuchashippocampusandisinducedintheregeneratingliver,suggestingthatCRE-BP1isimportantforbothsignaltransductioninthebrainandcellularproliferation.Inthemajorityofpatientswithacutemyeloidleukemia(AML),CREBwasfoundtobeoverexpressedinthebonemarrowandthisoverexpressionwasassociatedwithpoorprognosis.CREB5(CRE-Bpa)consistsof508aminoacidsandhasamolecularweightof56,840.CREB5ishighlyhomologouswithCRE-BP1infourregions:twoofthemaretheregionscontainingtheputativemetalfingerortheDNA-bindingdomainconsistingofthebasicaminoacidclusterandtheleucinezipper.BindstothecAMPresponseelementandactivatestranscription.
ProductReferences
1)SiuYTandJinDY.,(2007)FEBSJ.274(13):3224-3232.(General)
2)NomuraNetal.,(1993)JBiolChem.268(6):4259-4266.(General)
2)NomuraNetal.,(1993)JBiolChem.268(6):4259-4266.(General)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
