Specifications&Handling:

Properties
Source/Host	MouseSpleen
Sequence	Mouse20SImmunoproteasome.
Crossreactivity	Mouse
MW	~700kDa
Purity	≥95%(SDS-PAGE)
Formulation	Liquid.
OtherProductData	Use:AbletodegradesubstratesinanATP-independentmanner.ItcanbeactivatedchemicallywithSDS(0.035%)orbytheadditionofPA28.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.Werecommendaninitialproteinconcentrationof0.5-5nM.
Origin	ManufacturedbyBostonBiochem
ProductType	Protein
ShippingandHandling
Shipping	DRYICE
ShortTermStorage	-20°C
LongTermStorage	-80°C
HandlingAdvice	Aliquottoavoidfreeze/thawcycles.
Use/StABIlity	Stableforatleast1yearafterreceiptwhenstoredat-80°C.

Description:

The20SImmunoproteasomeisamodifiedformoftheconstitutivelyactive20SProteasomecoreparticleandisthecatalyticsubunitofthemulti-compleximmunoproteasome.Thestructureofthe20SImmunoproteasomeissimilartothe20SProteasome,whichiscomposedof28non-identicalsubunitsarrangedintofourstackedrings.However,during20SImmunoproteasomeassembly,thethreecatalyticβsubunits,β1,2,and5,inthetwointeriorringsofthe20SProteasomearereplacedbythreeIFN-γ-inducIBLecatalyticsubunits:β1i/LMP2,β2i/LMP7,andβ5i/MECL-1.The20SImmunoproteasomeiscommonlyassociatedwiththe19S,PA28α/β,orthePA28γregulatorycomplexes.20SImmunoproteasomeexpressionisenrichedinantigenpresentingcellsoftheimmunesystemwherethe20SImmunoproteasomeselectivelydegradesintracellularproteinsinamannerthatoptimizesthegenerationofpeptidesforMHCclassIantigenpresentation.Selectiveinhibitionof20SImmunoproteasomeproteolyticactivityusingsmallmoleculeinhibitorsisbeingexaminedfortherapeuticinterventionincancerandinflammatorydiseases.

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。